Small animal models of heart failure

AbstractHeart disease is a major cause of death worldwide with increasing prevalence, which urges the development of new therapeutic strategies. Over the last few decades, numerous small animal models have been generated to mimic various pathomechanisms contributing to heart failure (HF). Despite some limitations, these animal models have greatly advanced our understanding of the pathogenesis of the different aetiologies of HF and paved the way to understanding the underlying mechanisms and development of successful treatments. These models utilize surgical techniques, genetic modifications, and pharmacological approaches. The present review discusses the strengths and limitations of commonly used small animal HF models, which continue to provide crucial insight and facilitate the development of new treatment strategies for patients with HF.
Source: Cardiovascular Research - Category: Cardiology Source Type: research

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AimGuanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT–/– mice exhibit normal exercise capacity and response to ischemic heart failure. However, we hypothesized long-term consequences of Cr deficiency and/or accumulation of the Cr precursor guanidinoacetate (GA).MethodsCardiac function and metabolic profile were studied in GAMT–/– mice>1 year.ResultsIn vivo LV catheterization revealed lower heart rate and developed pressure in aging GAMT–/– but normal lung weight and ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
New research has shown that by changing the time course of voltage change early when the heart cell contracts it is possible to both withhold a potentially lethal electrical disturbance and improve the strength of cardiac contraction in heart failure at the same time.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Health, International, Research; Faculty of Life Sciences, Faculty of Life Sciences, School of Physiology, Pharmacology and Neuroscience; Press Release Source Type: news
Well, it’s been a really rough three weeks. The first thing that happened was on January 1, no kidding, when I came down with a case of the flu (much worse than the before-Xmas flu). It’s going around. A lot of people are sick with this thing. Anyway, it hit me with a very high fever and huge gastrointestinal issues. Terrible. Plus, one night, delirious with fever, I fell against the bathroom wall and injured my wrist. Ouch. Because my wrist was all swollen and hurt like the dickens, and I feared it might be fractured, Stefano took me to the emergency room at Florence’s university hospital, Careggi. We sp...
Source: Margaret's Corner - Category: Cancer & Oncology Authors: Tags: Blogroll cat Source Type: blogs
(University of Bristol) New research has shown that by changing the time course of voltage change early in action potential it is possible to both withhold a potentially lethal electrical disturbance and improve the strength of cardiac contraction in heart failure at the same time.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Acute heart failure is a rapid onset of new or worsening of signs and symptoms of heart failure that requires hospitalization or a visit to the emergency department. The aim of this study was to evaluate treat...
Source: BMC Cardiovascular Disorders - Category: Cardiology Authors: Tags: Research article Source Type: research
AbstractOver the recent years, studies have emerged reporting on a strong relationship between the occurrence of malignancy and Takotsubo syndrome. The aim of this systematic review and meta-analysis is to evaluate the predictive value of malignancy for prognosis of Takotsubo syndrome patients. PubMed, EMBASE, Cochrane Library, Web of science, and Scopus were searched until 4 September 2019 for articles concerning association of malignancy with the prognosis of Takotsubo syndrome. A total of ten studies were finally included in this meta-analysis, demonstrating that malignancy was associated with higher mortality in Takots...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
AbstractReceptor tyrosine kinases (RTKs) are implicated in cardiovascular growth and remodelling. We aimed to identify the plasma levels of RTKs and related proteins and their association with haemodynamic alterations in heart failure (HF) and related pulmonary hypertension (PH) following heart transplantation (HT). Using proximity extension assay, 28 RTKs and related proteins were analysed in plasma from 20 healthy controls and 26 HF patients before and 1-year after HT. In end-stage HF, out of 28 RTKs, plasma vascular endothelial growth factor-D (VEGF-D) and human epidermal growth factor-4 (HER4) were elevated compared to controls (p 
Source: Heart and Vessels - Category: Cardiology Source Type: research
ász Csanádi Vígh Bácskay BGP-15 is a new insulin sensitizer drug candidate, which was developed by Hungarian researchers. In recent years, numerous research groups have studied its beneficial effects. It is effective in the treatment of insulin resistance and it has protective effects in Duchenne muscular dystrophy, diastolic dysfunction, tachycardia, heart failure, and atrial fibrillation, and it can alleviate cardiotoxicity. BGP-15 exhibits chemoprotective properties in different cytostatic therapies, and has also proven to be photoprotective. It can additionally have advantageou...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
ConclusionsSurvey results highlight that cardiologists in Switzerland would benefit from information on the latest advances in ATTR to support them in screening heart failure patients and ensure that patients benefit from treatment advances.
Source: Cardiology and Therapy - Category: Cardiology Source Type: research
Conclusion: The presence of clinically significant TR is associated with an increase in healthcare utilization and expenditures, irrespective of the presence of HF. PMID: 31952454 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
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