Corrigendum to: A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity

Corrigendum to: A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity [Cardiovasc Res 2019;doi:10.1093/cvr/cvz148].
Source: Cardiovascular Research - Category: Cardiology Source Type: research

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Publication date: 22 January 2020Source: Neuron, Volume 105, Issue 2Author(s): Cinzia Vicidomini, Nannan Guo, Amar SahayRadial glia-like neural stem cells (RGLs) in the dentate gyrus subregion of the hippocampus give rise to dentate granule cells (DGCs) and astrocytes throughout life, a process referred to as adult hippocampal neurogenesis. Adult hippocampal neurogenesis is sensitive to experiences, suggesting that it may represent an adaptive mechanism by which hippocampal circuitry is modified in response to environmental demands. Experiential information is conveyed to RGLs, progenitors, and adult-born DGCs via the neur...
Source: Neuron - Category: Neuroscience Source Type: research
Authors: Traynelis SF, Dlugos D, Henshall D, Mefford HC, Rogawski MA, Staley KJ, Dacks PA, Whittemore V, Poduri A, National Institutes of Neurological Disorders and Stroke (NINDS)/American Epilepsy Society (AES) Epilepsy Research Benchmark Stewards Abstract The goals of Epilepsy Benchmark Area III involve identifying areas that are ripe for progress in terms of controlling seizures and patient symptoms in light of the most recent advances in both basic and clinical research. These goals were developed with an emphasis on potential new therapeutic strategies that will reduce seizure burden and improve quality of lif...
Source: Epilepsy Currents - Category: Neurology Tags: Epilepsy Curr Source Type: research
ConclusionThe differentiation of ADSCs into osteoblasts is significantly inhibited by ZOL. Due to this reason, it may be difficult to achieve good results by ZOL induced ADSCs into osteoblasts in repairing jaw necrosis.
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Publication date: Available online 22 January 2020Source: Life SciencesAuthor(s): Changzhe Chen, Chenxi Song, Dong Zhang, Dong Yin, Rui Zhang, Jingzhou Chen, Kefei DouAbstractAimsTo explore whether the combination of atorvastatins and resveratrol is superior to each individual drug alone regarding re-endothelialization after drug-eluting stents (DESs) implantation.Materials and methodsNinety-four rabbits were randomized into control, atorvastatin, resveratrol, and combined medication groups. Abdominal aorta injury was induced via ballooning, followed by DES implantation. Neointimal formation and re-endothelialization after...
Source: Life Sciences - Category: Biology Source Type: research
Source: Anti-Cancer Agents in Medicinal Chemistry - Category: Cancer & Oncology Authors: Tags: Review article Source Type: research
Neuropathic pain causes severe suffering, and most patients are resistant to current therapies. A core element of neuropathic pain is the loss of inhibitory tone in the spinal cord. Previous studies have shown that foetal GABAergic neuron precursors can provide relief from pain. However, the source of these precursor cells and their multipotent status make them unsuitable for therapeutic use. Here, we extend these findings by showing, for the first time, that spinally transplanted, terminally differentiated human induced pluripotent stem cell-derived GABAergic (iGABAergic) neurons provide significant, long-term, and safe r...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Publication date: Available online 21 January 2020Source: CytotherapyAuthor(s): Kavitha Govarthanan, Prasanna Vidyasekar, Piyush Kumar Gupta, Nibedita Lenka, Rama Shanker VermaAbstractAimMesenchymal stem cells (MSCs) are immunomodulatory, non-teratogenic and multipotent alternatives to embryonic or induced pluripotent stem cells (ESCs or iPSCs). However, the potency of MSCs is not equivalent to the pluripotency of ESCs or iPSCs. We used CHIR 99021 to improve current protocols and methods of differentiation for the enhanced transdifferentiation potency of MSCs.Main MethodsWe used Flurescence activated cell sorter (FACS) for...
Source: Cytotherapy - Category: Cytology Source Type: research
Contributors : L F Lorenzo-Mart ín ; Xosé R BusteloSeries Type : Expression profiling by arrayOrganism : Mus musculusEpidermal stem cells ensure proper faring of skin homeostatic processes under both physiological and challenging conditions. Currently, the molecular events underpinning ageing within the epidermal stem cell niche are poorly understood.Here, we report that epidermal stem cells are endowed with a collection of time-sensitive genes which constitute specific functional programs that become deregulated in an age-dependent manner.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Jan T Czerminski ; Jeanne B LawrenceSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlthough Down Syndrome (DS) is the leading genetic cause of intellectual disability in children, the developmental pathogenesis remains largely unknown, and better strategies are needed to investigate this. We previously showed that one copy of chromosome 21 can be epigenetically silenced in DS iPSCs by insertion of an XIST transgene, which produces a non-coding RNA that normally silences one X chromosome in female cells. XIST was shown to induce heterochromatin and silence transcription...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
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