Generation of four iPSC lines from two siblings with a microdeletion at the CNTN6 gene and intellectual disability

Publication date: Available online 21 October 2019Source: Stem Cell ResearchAuthor(s): T.A. Shnaider, I.E. Pristyazhnyuk, A.G. Menzorov, N.M. Matveeva, A.A Khabarova, N.A. Skryabin, A.A. Kashevarova, M.E. Lopatkina, L.P. Nazarenko, I.N. Lebedev, O.L. SerovAbstractThe human induced pluripotent stem cell (iPSC) lines, ICGi009-A, ICGi009-B, ICGi013-A and ICGi013-B, were generated from skin fibroblasts of two siblings with intellectual disability. Both patients were carriers of CNTN6 gene microdeletion(Kashevarova et al., 2014). iPSC lines have normal karyotype, express pluripotency markers, are able to differentiate in vitro into derivatives of all three germ layers and represent a unique tool to study neurodevelopmental disorders.
Source: Stem Cell Research - Category: Stem Cells Source Type: research