Generation of human induced pluripotent stem cell lines from patients with selective IgA deficiency

Publication date: Available online 22 October 2019Source: Stem Cell ResearchAuthor(s): Jonathan Arias-Fuenzalida, Jingwei Yu, Likun Du, Joaquin Custodio, Luigi D. Notarangelo, Lennart Hammarström, Qiang Pan-HammarströmAbstractSelective immunoglobulin-A deficiency (IgAD) is the most common primary immunodeficiency (PID) in the Western world and results in higher susceptibility to infections, autoimmune disorders and malignancies. We generated human induced pluripotent stem cell lines from two patients with selective immunoglobulin-A primary immunodeficiency, PHAi001 and PHAi002. Patient samples were reprogrammed using non-integrative based methods. Pluripotency of the PHAi001 and PHAi002 cell lines was confirmed by their expression of stem cell markers and capacity to differentiate into cells of the three germ layers. The PHAi001 and PHAi002 lines are a unique resource for experimental modeling of immunoglobulin-A deficiency and associated disorders.
Source: Stem Cell Research - Category: Stem Cells Source Type: research