Inflammatory and pro-resolving mediators in frontotemporal dementia and Alzheimer’s disease

Publication date: Available online 22 October 2019Source: NeuroscienceAuthor(s): Vanêssa Gomes Fraga, Carolina Antunes Magalhães, Cristina de Mello Gomide Loures, Leonardo Cruz de Souza, Henrique Cerqueira Guimarães, Danielle Alves Gomes Zauli, Maria das Graças Carvalho, Cláudia Nathália Ferreira, Paulo Caramelli, Lirlândia Pires de Sousa, Karina Braga GomesAbstractChronic inflammation contributes to neuronal death in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Here we evaluated inflammatory and pro-resolving mediators in AD and behavioural variant of FTD (bvFTD) patients compared with controls, since neuroinflamamtion is a common feature in both diseases. Ninety-eight subjects were included in this study, divided into AD (n = 32), bvFTD (n = 30), and control (n = 36) groups. The levels of hsCRP, IL-1β, IL-6, TNF, and TGF-β1, as well as annexin A1 (AnxA1) and lipoxin A4 (LXA4) were measured in blood and cerebrospinal fluid (CSF). The expression profile of AnxA1 was evaluated in peripheral blood mononuclear cells (PBMCs) as well the distribution of ANXA1 rs2611228 polymorphism. We found reduced peripheral levels of hsCRP and TNF in AD compared with bvFTD patients and controls, and increased levels of TGF-β1 in AD compared to controls. Moreover, reduced plasma levels of AnxA1 were observed in bvFTD compared to AD and controls. There was a significant cleavage of AnxA1 in PBMCs in both dementia groups. The results suggest differential regulation of in...
Source: Neuroscience - Category: Neuroscience Source Type: research