Association between ribs shape and pulmonary function in patients with Osteogenesis Imperfecta

Publication date: Available online 22 October 2019Source: Journal of Advanced ResearchAuthor(s): Juan A. Sanchis-Gimeno, Stephanie Lois-Zlolniski, José María González-Ruiz, Carlos A. Palancar, Nicole Torres-Tamayo, Daniel García-Martínez, Luis Aparicio, Marcelino Perez-Bermejo, Esther Blanco-Perez, Federico Mata-Escolano, Susanna Llidó, Isabel Torres-Sanchez, Francisco García-Río, Markus BastirAbstractThe aim of the present study was to test the hypothesis that ribs shape changes in patients with OI are more relevant for respiratory function than thoracic spine shape. We used 3D geometric morphometrics to quantify rib cage morphology in OI patients and controls, and to investigate its relationship with forced vital capacity (FVC) and forced expiratory volume in 1s (FEV1), expressed as absolute value and as percentage of predicted value (% pred). Regression analyses on the full sample showed a significant relation between rib shape and FEV1, FVC and FVC % pred whereas thoracic spine shape was not related to any parameter. Subsequent regression analyses on OI patients confirmed significant relations between dynamic lung volumes and rib shape changes. Lower FVC and FEV1 values are identified in OI patients that present more horizontally aligned ribs, a greater antero-posterior depth due to extreme transverse curve at rib angles and a strong spine invagination, greater asymmetry, and a vertically short, thoraco-lumbar spine, which is relatively straight in at levels 1-8 a...
Source: Journal of Advanced Research - Category: Research Source Type: research