Cardiac Glycosides, a Category that Includes Several Approved Drugs, are Found to be Senolytic
In this study it was found that cardiac glycosides selectively eliminate many types of senescent cells, including when senescence has been triggered by irradiation, cancer itself, or chemotherapeutic drugs - such as etoposide or doxorubicin. The fact that ouabain can eliminate different types of senescent cells emphasises its potential as a broad spectrum senolytic.
"These drugs are already used in the clinic, so they could be repurposed to treat a long list of diseases including cancer. This is something we are keen to explore with our clinical collaborators. Moreover, many patients are being treated with digoxin and an epidemiologist could look retrospectively and ask the question of whether those patients who were treated with digoxin are doing better than those who weren't."
Link: https://lms.mrc.ac.uk/repurposing-heart-drugs-to-target-cancer-cells/
Source: Fight Aging! - Category: Research Authors: Reason Tags: Daily News Source Type: blogs
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