Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice

Mucosal Immunology, Published online: 21 October 2019; doi:10.1038/s41385-019-0217-6Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice
Source: Mucosal Immunology - Category: Allergy & Immunology Authors: Source Type: research

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This article updates our laboratory's systematic search for antigens using bioinformatics tools to clarify the Mtb H37Rv Rv3632 protein's topology and location. This article reports a C-terminal region consisting of peptides 39255 and 39256 (81Thr-Arg114) having high specific binding regarding two infection-related cell lines (A549 and U937); they inhibited mycobacterial entry to U937 cells in a concentration-dependent manner. Rv3632 forms part of the mycobacterial cell envelope, formed by six linear synthetic peptides. Circular dichroism enabled determining the protein's secondary structure. It was also found that peptide...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusion: There was not enough evidence from our data to support that Beijing strains were more infective than non-Beijing strains in TB transmission in school setting. PMID: 31111051 [PubMed - indexed for MEDLINE]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
ConclusionsResistant MTB isolates in Algeria harbour resistance genotypes similar to other countries, but some rare patterns may result from selection and transmission processes inherent to the country.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
CONCLUSIONS: As far as we know, this is the first case reported of a suppurative fistula after the resection of a cerebral abscess caused by M. bovis, therefore, there is no report in the literature about the treatment of this complication. PMID: 31713228 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
Publication date: November–December 2019Source: Journal of the American Society of Cytopathology, Volume 8, Issue 6Author(s): Dianna L. Ng, Ronald BalassanianIntroductionFine-needle aspiration biopsy (FNAB) is a minimally invasive biopsy technique and an important tool for diagnosing infectious diseases. Rapid onsite evaluation allows for triage for ancillary testing, including microbiologic cultures. We aimed to determine the etiology of granulomatous inflammation diagnosed by FNAB by correlating with culture results and clinical history.Materials and methodsA 16-year retrospective review of cases diagnosed as &ldqu...
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
Publication date: Available online 12 November 2019Source: Clinica Chimica ActaAuthor(s): Laisheng Li, Yingsheng Yao, Jianbo Liang, Xiaoxia Zhan, Fen Wang, Caifeng Yue, Ben-Quan Wu, Shengfeng Hu, Min Liu, Jianxin Wan, Jinmei LuoAbstractBackgroundHuman epididymis protein 4 (HE4) has been recognized as a biomarker which elevated in various diseases. The aim of this study was to evaluate the value of serum HE4 in pulmonary tuberculosis (PTB).MethodsSerum HE4 concentrations were determined in 127 PTB, 88 chronic bronchitis (CHB), and 105 healthy control subjects by chemiluminescent microparticle immunoassay. Receiver operating...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
MultiCare Auburn Medical Center in Washington is notifying the workers, patients and their families that a hospital employee may have exposed them to tuberculosis between April and September.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 13 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Kiel Hards, Cara Adolph, Liam K. Harold, Matthew B. McNeil, Chen-Yi Cheung, Adrian Jinich, Kyu Y. Rhee, Gregory M. CookAbstractCellular bioenergetics is an area showing promise for the development of new antimicrobials, antimalarials and cancer therapy. Enzymes involved in central carbon metabolism and energy generation are essential mediators of bacterial physiology, persistence and pathogenicity, lending themselves natural interest for drug discovery. In particular, succinate and malate are two major focal po...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 12 November 2019Source: Journal of Theoretical BiologyAuthor(s): Mohammad Hassan Nematollahi, Ramin Vatankhah, Mojtaba SharifiAbstractTuberculosis is one of deadly diseases in many countries that attacks to the human body and causes damage to the lung, causing bloody coughing and if left untreated, it will kill half of the affected people. Tuberculosis bacteria can stay latent and reactivate after passing appropriate conditions. For this reason, control of this disease and treatment of infected people has a significant importance, and observing health issues can prevent the spread of it. ...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
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