Stability Indicating RP-HPLC Method for Simultaneous Determination of Omeprazole and Aspirin in the Presence of Salicylic Acid as Degradation Product

Publication date: Available online 20 October 2019Source: Microchemical JournalAuthor(s): Amira H. Kamal, Aya A. Marie, Sherin F. HammadAbstractReversed-phase high performance liquid chromatographic method (RP-HPLC) was applied for simultaneous determination of aspirin (ASP) and omeprazole (OMP) in presence of salicylic acid (SA) as the most common degradation product of ASP. The drugs were exposed to different stress conditions including acid, alkali, neutral hydrolysis, oxidation, and photodegradation. The separation was carried out on the Thermo Scientific Hypersil ODS column (250 × 4.6 mm, 5µm) column. Mobile phase composed of acetonitrile: 0.05M sodium phosphate monobasic buffer with 0.1% TEA (23:77, v/v). The pH of the buffer was adjusted to pH 3.5 with o-phosphoric acid. The flow rate was 1.2 mL/min. The UV detector was set at 230nm. The retention time of SA, ASP and OMP were 3.51±0.19 min, 4.77± 0.23min, and 16.65±0.34 min, respectively. Linearity was established for in the range of 1-150 µg/mL for ASP, 2-80 µg/mL for OMP and 1-25 µg/mL for SA. The mean percentage recoveries of ASP, OMP and SA were found to be 99.89% ±0.39, 99.76% ±0.38 and 100.28% ±0.18, respectively. The developed method was validated and successfully applied to the simultaneous determination of ASP and OMP in their tablets. The assay results obtained using the developed method were statistically compared to those obtained b...
Source: Microchemical Journal - Category: Chemistry Source Type: research

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Publication date: Available online 16 November 2019Source: Journal of Health EconomicsAuthor(s): Dimitris Christelis, Dimitris Georgarakos, Anna Sanz-de-GaldeanoAbstractEconomic theory predicts that a reduction in background risk should induce financial risk-taking, particularly for individuals with low stock market participation costs. Hence, health insurance coverage could affect financial risk-taking by offsetting health-related background risk. We use a regression discontinuity design to examine whether Medicare eligibility at age 65 increases stockholding in the US and find that it does so for those with college educa...
Source: Journal of Health Economics - Category: Health Management Source Type: research
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Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 17 November 2019Source: European UrologyAuthor(s): Tom Marcelissen, Kevin Rademakers
Source: European Urology - Category: Urology & Nephrology Source Type: research
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Source: European Urology - Category: Urology & Nephrology Source Type: research
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Source: European Urology - Category: Urology & Nephrology Source Type: research
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Source: European Urology - Category: Urology & Nephrology Source Type: research
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Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
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Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
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Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
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