Stability Indicating RP-HPLC Method for Simultaneous Determination of Omeprazole and Aspirin in the Presence of Salicylic Acid as Degradation Product
Publication date: Available online 20 October 2019Source: Microchemical JournalAuthor(s): Amira H. Kamal, Aya A. Marie, Sherin F. HammadAbstractReversed-phase high performance liquid chromatographic method (RP-HPLC) was applied for simultaneous determination of aspirin (ASP) and omeprazole (OMP) in presence of salicylic acid (SA) as the most common degradation product of ASP. The drugs were exposed to different stress conditions including acid, alkali, neutral hydrolysis, oxidation, and photodegradation. The separation was carried out on the Thermo Scientific Hypersil ODS column (250 × 4.6 mm, 5µm) column. Mobile phase composed of acetonitrile: 0.05M sodium phosphate monobasic buffer with 0.1% TEA (23:77, v/v). The pH of the buffer was adjusted to pH 3.5 with o-phosphoric acid. The flow rate was 1.2 mL/min. The UV detector was set at 230nm. The retention time of SA, ASP and OMP were 3.51±0.19 min, 4.77± 0.23min, and 16.65±0.34 min, respectively. Linearity was established for in the range of 1-150 µg/mL for ASP, 2-80 µg/mL for OMP and 1-25 µg/mL for SA. The mean percentage recoveries of ASP, OMP and SA were found to be 99.89% ±0.39, 99.76% ±0.38 and 100.28% ±0.18, respectively. The developed method was validated and successfully applied to the simultaneous determination of ASP and OMP in their tablets. The assay results obtained using the developed method were statistically compared to those obtained b...
Publication date: Available online 16 November 2019Source: Journal of Health EconomicsAuthor(s): Dimitris Christelis, Dimitris Georgarakos, Anna Sanz-de-GaldeanoAbstractEconomic theory predicts that a reduction in background risk should induce financial risk-taking, particularly for individuals with low stock market participation costs. Hence, health insurance coverage could affect financial risk-taking by offsetting health-related background risk. We use a regression discontinuity design to examine whether Medicare eligibility at age 65 increases stockholding in the US and find that it does so for those with college educa...
In this study, serum IL6 was measured by ELISA, and the HSD11B1rs12086634(T/G) polymorphism was analyzed using a TaqMan allelic discrimination assay technique. There were statistically significant differences between the two studied groups concerning the serum IL-6 level and HSD11B1rs12086634(T/G) genotype distribution, with increased serum IL6 and increased frequencies of the GG and TG genotypes in patients with PCO. The GG genotype of HSD11B1 rs12086634(T/G) and its associated high level of serum IL-6 may represent genetic risk factors for PCOS.
Publication date: Available online 17 November 2019Source: European UrologyAuthor(s): Tom Marcelissen, Kevin Rademakers
Publication date: Available online 17 November 2019Source: European UrologyAuthor(s): Zhengzheng Xu, Guangzhe Ge, Bao Guan, Zhentao Lei, Xueyu Hao, Yuanyuan Zhou, Yue Shi, Huan Lu, Jilu Wang, Ding Peng, XiKang Wu, Huiying He, Bao Zhang, Xuesong Li, Liqun Zhou, Weimin Ci
Publication date: Available online 16 November 2019Source: European UrologyAuthor(s): Pirus Ghadjar, Thomas Wiegel
Publication date: Available online 16 November 2019Source: European UrologyAuthor(s): Elise De Bleser, Piet Ost
ConclusionThe CFQL-2 is a brief, reliable scale that effectively measures psychosocial aspects of QoL and is sensitive to changes in QoL in families of children with ASD or related neurodevelopmental disorders. Child externalizing behavior is strongly associated with reductions in multiple aspects of child and family psychosocial QoL.
ConclusionThis meta-analysis suggested a significant association between MTHFR gene polymorphism (C677T and A1298C) and ASD risk.
ConclusionGiven that obtaining negative margins is important in reducing the risk of recurrence, the method of surgical resection utilized is based on the amount of future functional residual hepatic parenchyma.
ConclusionsTattooing of axillary LNs is safe and easily performed. Tattooing was helpful in identifying the marked LN in the majority of cases. This technique helps to ensure that metastatic LNs are identified and removed at surgery after NAT.