Novel pH-responsive biodegradable organosilica nanoparticles as drug delivery system for cancer therapy

Publication date: Available online 20 October 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Shun Yang, Jie Fan, Shiting Lin, Yaru Wang, Chang LiuAbstractAlthough the biodegradability of silica has been verified, the complete and safe excretion of mesoporous silica nanoparticles (MSNs) from the biological system still impede their clinical translation. Herein, novel pH-responsive biodegradable hollow mesoporous organosilica nanoparticles (PBHMONs) based on pH-responsive silsesquioxane were successfully prepared for efficient anti-cancer drug delivery. pH-responsive cleavable bridges containing acetal moieties were prepared and then inserted directly into the framework of the MONs and the hollow nanostructures were achieved by silica-etching chemistry (alkaline etching). PBHMONs exhibited particularly high drug loading capacities for drugs (DOX) owing to the hollow mesoporous structure, and a uniquely low premature leakage owing to π-π interactions. Moreover, the pH-responsive biodegradation of the PBHMONs in the weakly acidic microenvironment of tumor cells led to partial drug release, as well as potential enabling rapid excretion and preventing long-term retention/toxicity.Graphical abstract
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research

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In this study, a redox-sensitive CPT-OA conjugate containing the disulfide bond (CPT-SS-OA) was used to deliver the lactone-stabilized CPT for the improved antitumor efficacy. A non-sensitive CPT-OA was used as control to illuminate the role of disulfide bond. Both CPT-SS-OA and CPT-OA formulated in cremophor EL micelles (CM) displayed multiple therapeutic advantages: small diameter (∼14 nm), efficient cellular internalization, prolonged blood circulation, and favorable biodistribution. However, only CPT-SS-OA/CM achieved the superior chemotherapeutic efficacy over CPT solution in the Lewis lung carcinoma (LLC) cancer ...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Publication date: Available online 18 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Lan Huang, Cindy Wang, Huaxi Xu, Guangyong PengAbstractAn important feature shared by many cancer cells is drastically altered metabolism that is critical for rapid growth and proliferation. The distinctly reprogrammed metabolism in cancer cells makes it possible to manipulate the levels of metabolites for cancer treatment. Citrate is a key metabolite that bridges many important metabolic pathways. Recent studies indicate that manipulating the level of citrate can impact the behaviors of both cancer ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research
Nature, Published online: 20 November 2019; doi:10.1038/s41586-019-1758-2Publisher Correction: Harnessing innate immunity in cancer therapy
Source: Nature AOP - Category: Research Authors: Source Type: research
Publication date: Available online 18 November 2019Source: Life SciencesAuthor(s): Kosar Babaei, Shima Shams, Arman Keymoradzadeh, Sogand Vahidi, Parisa Hamami, Roya Khaksar, Seyedeh Elham Norollahi, Ali Akbar SamadaniAbstractImportance of dysregulation and expression of microRNAs (miRNAs) has been confiemed in many disorders comprising cancer. In this way, different approaches to induce reprogramming from one cell type to another in oerder to control the cell normal mechanisem, comprising microRNAs, combinatorial small molecules, exosome-mediated reprogramming, embryonic microenvironment and also lineage-specific transcri...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 18 November 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Juan Liao, Siyu Peng, Mei Long, Yaya Zhang, Huaming Yang, Yi Zhang, Jing HuangAbstractNatural halloysite clay nanotubes (halloysite nanotubes, HNTs) are potentially used in colon cancer therapy owing to their excellent physicochemical properties. However, the size-dependent interaction between HNTs and colon cancer cells is still an unresolved challenge. Herein, we analyzed the interfacial interactions between HNTs and colon cancer cells, and evaluated the size-dependent biological effects o...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: Available online 19 November 2019Source: Chemical Engineering JournalAuthor(s): Kai Chen, Shuangsi Liao, Shiwei Guo, Xiuli Zheng, Bing Wang, Zhenyu Duan, Hu Zhang, Qiyong Gong, Kui LuoAbstractBiocompatible, stimuli-responsive, intelligent and efficient drug delivery systems are essential for effectively suppressing cancer and reducing toxic side effects of chemotherapeutic drugs. Herein, two strategies have been employed to develop a N-(1,3-dihydroxypropan-2-yl) methacrylamide (DHPMA)-derived polymer carrier for doxorubicin (DOX) with a long circulation time: increasing molecular weight (MW) of the DHPMA ...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ04763H, PaperDawei Jiang, Tao Yue, Guicheng Wang, Chaochao Wang, Chao Chen, Hongliang Cao, Yun Gao Due to biological safety and negligible toxicity, nitric oxide (NO) therapy has gained increasing interest in the field of cancer therapy during past few years. However, individual NO cancer therapy... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: Available online 17 November 2019Source: European Polymer JournalAuthor(s): Samson O. Aisida, Paul A. Akpa, Ishaq Ahmad, Ting-kai Zhao, M. Maaza, Fabian I. EzemaAbstractCancer cells are typified by proliferating mass of cells that grow faster than other smaller cell tissues within the body. Efforts to combat this effect through chemotherapy, radiotherapy, immunotherapy and surgery are still challenging. Magnetic Iron oxide nanoparticles (FeO-NPs) encapsulated with biopolymers as a local drug delivery system with the control via an external magnetic field has been widely used as a drug delivery system in c...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Authors: Elkhenany H, Shekshek A, Abdel-Daim M, El-Badri N Abstract Hepatocellular carcinoma (HCC) is one of the most common types of cancer and results in a high mortality rate worldwide. Unfortunately, most cases of HCC are diagnosed in an advanced stage, resulting in a poor prognosis and ineffective treatment. HCC is often resistant to both radiotherapy and chemotherapy, resulting in a high recurrence rate. Although the use of stem cells is evolving into a potentially effective approach for the treatment of cancer, few studies on stem cell therapy in HCC have been published. The administration of stem cells from...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Curative cancer therapies are uncommon and nearly always involve multi-drug combinations developed by experimentation in humans; unfortunately, the mechanistic basis for the success of such combinations has rarely been investigated in detail, obscuring lessons learned. Here we use isobologram analysis to score pharmacological interaction, and clone tracing and CRISPR screening to measure cross-resistance among the five drugs comprising R ‑CHOP, a combination therapy that frequently cures Diffuse Large B-Cell Lymphomas. We find that drugs in R‑CHOP exhibit very low cross-resistance but not synergistic interaction: toget...
Source: eLife - Category: Biomedical Science Tags: Cancer Biology Computational and Systems Biology Source Type: research
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