Paget's disease of bone in two medieval skeletons from Poulton Chapel, Cheshire, UK

This study reviews an adult male (SK463) and female (SK750) with skeletal lesions of PDB from Poulton Chapel, Cheshire. Full macroscopic and radiographic analysis has identified the skeletal distribution of PDB, with up to 75% of both skeletons affected. SK463 presents noticeable anterior bowing to both tibiae, likely the result of PDB. AMS radiocarbon dating and stable isotope analysis performed on teeth samples confirmed that both individuals' dates were medieval, had a mixed/varied diet and were local to the northwest of England. This research adds to the emerging paleopathological literature on PDB, while providing additional support for the identification of a geographical hotspot observed in contemporary populations.
Source: International Journal of Osteoarchaeology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research

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This study reviews an adult male (SK463) and female (SK750) with skeletal lesions of PDB from Poulton Chapel, Cheshire. Full macroscopic and radiographic analysis has identified the skeletal distribution of PDB, with up to 75% of both skeletons affected. SK463 presents noticeable anterior bowing to both tibiae, likely the result of PDB. AMS radiocarbon dating and stable isotope analysis performed on teeth samples confirmed that both individuals dates were medieval, had a mixed/varied diet and were local to the northwest of England. This research adds to the emerging paleopathological literature on PDB, while providing addi...
Source: International Journal of Osteoarchaeology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
ABSTRACTAn evidence ‐based clinical guideline for the diagnosis and management of Paget's disease of bone (PDB) was developed using GRADE methodology, by a Guideline Development Group (GDG) led by the Paget's Association (UK). A systematic review of diagnostic tests and pharmacological and nonpharmacological treatmen t options was conducted that sought to address several key questions of clinical relevance. Twelve recommendations and five conditional recommendations were made, but there was insufficient evidence to address eight of the questions posed. The following recommendations were identified as the most im portant:...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
Conclusions: The above multimodality imaging pictorial review highlights the imaging spectrum of Paget disease of the bone and helps in confident diagnosis of the disease and its associated complications; thereby improving patient management and avoiding unnecessary biopsies.​
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibits Source Type: research
AbstractJuvenile Paget ’s disease (JPD) is a rare autosomal recessive osteopathy. There is still a question about the most effective treatment modality in long-term prognosis. A 9-month-old boy who suffered from bone pain and deformities with a very high alkaline phosphatase level was diagnosed as JPD by radiographic fi ndings. Genetic analysis showed a homozygous large deletion inTNFRSF11B gene encoding osteoprotegerin. Clinical improvement was observed with intravenous pamidronate therapy. However, the effect of drug reduced in time so the annual dose per kilogram body weight was increased after 2  years. Desp...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Paget's disease of bone (PDB) is the second most common metabolic bone disease after osteoporosis, even if its prevalence is decreasing, as pointed out in two recent articles published in the Journal [1,2]. The prevalence of PDB is difficult to assess as the vast majority of the patients affected are asymptomatic and the disorder is focal in nature. The main surveys that attempted to determine its prevalence used standard radiographs of the pelvis or of the abdomen where the lumbar vertebrae, pelvis, sacrum and the upper part of both femurs can be observed, regions that are the most affected by the condition.
Source: Bone - Category: Orthopaedics Authors: Tags: Correspondence Source Type: research
The most common indications for the use of bisphosphonates and other antiresorptive agents are osteoporosis, Paget ’s disease, hyperparathyroidism, metastatic malignancy, hypercalcemia of malignancy, and multiple myeloma. These agents can have a significant impact on the oral environment, including bisphosphonate-related osteonecrosis of the jaw (BRONJ) and medicine-related osteonecrosis of the jaw (MRONJ). Some of the effects on the oral environment can be evident radiographically. Understanding these changes may help the dental practitioner plan treatment and better understand patients’ risks and th...
Source: Dental Abstracts - Category: Dentistry Tags: Hands On Source Type: research
Abstract The potential of platelet‐rich fibrin, (or leucocyte platelet‐rich fibrin), has been increasingly promoted for a range of oral and maxillofacial procedures. These include bone regeneration around implants, survival of bone grafts in implant surgery, third molar extraction sockets and periodontal regeneration, and as an adjunct to adipocyte grafts in facial lipostructure. L‐PRF is an autologous blood product that contains a rich host of cytokines and growth factors and has been shown to accelerate and improve results in hard and soft tissue wound healing. This case series explores the role of L‐PRF in conju...
Source: Oral Surgery - Category: ENT & OMF Authors: Tags: Case Report Source Type: research
Conclusions Although osteological analysis seemed more sensitive in identifying infectious and neoplastic lesions, radiological analysis often provided a clearer illustration of the extent of these conditions, especially when the lesion involved a large area (eg, osteoporosis or Paget disease). Radiological analysis suggested that, as they age, men accumulate skeletal lesions more rapidly than women. Using bioarchaeological data, our study suggests the potential that radiological analysis might have in the establishment of general baseline levels of ill health in both past and present populations.
Source: Academic Radiology - Category: Radiology Source Type: research
Contributors : Sanjay K Bhadada ; Vandana Dhiman ; Akhilesh Kumar ; K Rajagopal ; Ashutosh Arya ; Sameer Aggarwal ; DC Sharma ; Yashpal Gogate ; Anil Bhansali ; DS RaoSeries Type : Expression profiling by arrayOrganism : Homo sapiensGlobal microarray was performed from Trans-Iliac Bone biopsy from the patient with clinically characterized Fibrogensis imperfecta ossium (FIO). A 40-year-old male patient with clinically characterized Fibrogensis imperfecta ossium (FIO) includes fragility fracture with osteomalacia (Losser ’s zone). On examination, his height was 158 cm, weight 47 kg, body mass index (BMI) 16.5, and his...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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