IJERPH, Vol. 16, Pages 4031: Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors

IJERPH, Vol. 16, Pages 4031: Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204031 Authors: Cannizzaro Ramaci Cirrincione Plescia Work-related stress is a growing health problem in modern society. The stress response is characterized by numerous neurochemicals, neuroendocrine and immune modifications that involve various neurological systems and circuits, and regulation of the gene expression of the different receptors. In this regard, a lot of research has focused the attention on the role played by the environment in influencing gene expression, which in turn can control the stress response. In particular, genetic factors can moderate the sensitivities of specific types of neural cells or circuits mediating the imprinting of the environment on different biological systems. In this current review, we wish to analyze systematic reviews and recent experimental research on the physio-pathological mechanisms that underline stress-related responses. In particular, we analyze the relationship between genetic and epigenetic factors in the stress response.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research