Genes, Vol. 10, Pages 830: Molecular Characterization of Leishmania RNA virus 2 in Leishmania major from Uzbekistan
Genes, Vol. 10, Pages 830: Molecular Characterization of Leishmania RNA virus 2 in Leishmania major from Uzbekistan
Genes doi: 10.3390/genes10100830
Authors:
Yuliya Kleschenko
Danyil Grybchuk
Nadezhda S. Matveeva
Diego H. Macedo
Evgeny N. Ponirovsky
Alexander N. Lukashev
Vyacheslav Yurchenko
Here we report sequence and phylogenetic analysis of two new isolates of Leishmania RNA virus 2 (LRV2) found in Leishmania major isolated from human patients with cutaneous leishmaniasis in south Uzbekistan. These new virus-infected flagellates were isolated in the same region of Uzbekistan and the viral sequences differed by only nineteen SNPs, all except one being silent mutations. Therefore, we concluded that they belong to a single LRV2 species. New viruses are closely related to the LRV2-Lmj-ASKH documented in Turkmenistan in 1995, which is congruent with their shared host (L. major) and common geographical origin.
Source: Genes - Category: Genetics & Stem Cells Authors: Yuliya Kleschenko Danyil Grybchuk Nadezhda S. Matveeva Diego H. Macedo Evgeny N. Ponirovsky Alexander N. Lukashev Vyacheslav Yurchenko Tags: Article Source Type: research