Unraveling the osteocyte in CKD-MBD post –renal transplantation

Changes in indices of mineral metabolism, bone protein expression, and bone turnover were assessed between pre – and post–renal transplant bone biopsies obtained 12 months apart. Circulating sclerostin and fibroblast growth factor 23 (FGF-23) levels decreased, and a low bone turnover state was highly prevalent on follow-up. In contrast, bone sclerostin expression increased, whereas FGF-23 bone expression was unchanged/decreased. These findings underscore the limitations of circulating biomarkers and the critical role of bone biopsy to understand osteocyte biology in chronic kidney disease–mineral bone disorder.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research