The authors reply

We thank El Karoui and colleagues for their comments.1 We think that both studies, theirs and ours,2,3 show that severe hypertension is a characteristic feature of atypical hemolytic uremic syndrome (aHUS). Even their patients classified as aHUS not associated with hypertensive emergencies had a median blood pressure of 154/90 mm  Hg, which would include hypertension grades 1-2, according to the 2018 European Society of Cardiology/European Society of Hypertension guidelines.4 Unlike in their study, we found a favorable effect of eculizumab also in patients with severe and malignant hypertension.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research