Omega3 Wound Fish Skin Graft in the Treatment of DFUs

Condition:   Diabetic Foot Ulcer Interventions:   Device: Kerecis Omega3 Wound;   Device: Fibracol Sponsor:   Kerecis Ltd. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/ The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: MSC can be divided into immune-tolerant and pro-rejection types in organ transplantation and Netrin-1 can induce the transformation of MSC from the pro-rejection to immune-tolerant type and markedly prolong the skin graft survival time. PMID: 31696460 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: This reconstructive strategy provides a quick and straightforward single-stage option for the reconstruction of complex cutaneotendinous defects of the dorsum of the hand. Such a reconstruction, with a completely vascularized procedure, is particularly indicated in cases of high contamination or infection of the recipient site. PMID: 31698492 [PubMed - in process]
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research
Researchers continue to take incremental steps towards the creation of engineered living tissues containing the vascular networks needed to support it. Absent blood vessels, numerous varieties of functional tissue can be generated from cell samples: lung, liver, kidney, and so forth. These organoids are limited in size to a few millimeters, however, the distance the nutrients and oxygen can perfuse. Generating blood vessel networks is a serious technical challenge, and the major obstacle to the production of entire organs for transplantation. Consider that natural capillary networks exhibit a density of hundreds of vessels...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ConclusionOne year postoperative with popliteal resection surgery yields a good result. A follow-up is needed for risk of recurrence and malignancy.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
In conclusion, modulation of keratin 5 expression and distribution either due to mutations or factors may account for the development of pigmentary disorders. PMID: 31692218 [PubMed - as supplied by publisher]
Source: Pigment Cell and Melanoma Research - Category: Cytology Authors: Tags: Pigment Cell Melanoma Res Source Type: research
New autologous skin regeneration technology yielded full ‐thickness skin as evidenced by clinical observation and skin biopsy 5 months after surgery, providing relief for debilitating split‐thickness skin graft contracture in pediatric burn case. AbstractNew autologous skin regeneration technology yielded full ‐thickness skin as evidenced by clinical observation and skin biopsy 5 months after surgery, providing relief for debilitating split‐thickness skin graft contracture in a pediactric burn case.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
Purpose of review Vascularized composite allotransplantation (VCA), a life-enhancing treatment for patients with complex tissue defects, trauma or illness, expounds upon the foundation of solid organ transplantation (SOT), the gold standard in end-stage organ failure. As innate and adaptive immunity remain the fundamental concern, this review highlights divergent immunobiology responses in VCA and SOT recipients. Recent findings Host innate immune activation drives peritransplant tissue ischemia–reperfusion injury (IRI). Despite the direct relationship between ischemia–reperfusion (IR)-stress and cell-medi...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: VASCULARIZED COMPOSITE ALLOTRANSPLANTATION: Edited by Linda C. Cendales Source Type: research
Researchers from Rensselaer Polytechnic Institute have developed a new method to 3D print living skin with built-in blood vessels. This living skin construct is cultured in vitro and develops into an interconnected microvascular network underneath a ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Dermatology Materials Medicine Plastic Surgery Rehab Vascular Surgery Source Type: blogs
In this study, we evaluated whether glycerol-cryopreservation could be applied in order to preserve inactivated skin by HHP using a porcine model. Twenty full-thickness skin grafts (1.5  × 1.5 cm) were prepared from a minipig. The skin samples were inactivated by the HHP in normal saline or glycerol/fructose solution, followed by cryopreservation for 5 weeks at − 80 °C in each same solution. Another 10 grafts immediately after inactivation were prepared as non-cryopres erved controls. Nine grafts in each group were randomly implanted on the fascia of a host pig and remove...
Source: Journal of Artificial Organs - Category: Transplant Surgery Source Type: research
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