Don't Throw Your Heart Away: Layperson Study 1
Condition: Transplant; Decision-making Interventions: Other: Total Survival; Other: Stratified Transplant Survival Sponsor: Carnegie Mellon University Not yet recruiting
Providence Heart Institute has appointed two new leaders to head the heart transplant program it is rebuilding eight years after it was discontinued. Dr. Brian Bruckner will serve as surgical director of the program. He was recruited from Methodist DeBakey Heart and Vascular Center in Houston, where he has served as the surgical director of the heart transplant program. "We’ve had a nationwide recruitment process for last several months and looked at a number of candidates who were very interested…
ConclusionsCardiac allografts deemed high-risk by utilization and survival based methods led to equivalent post-transplant survival as matched recipients with low-risk donors. This study demonstrates that traditionally high-risk donors may have been associated with worst post-transplant survival because of the recipients that utilized them. Therefore, accepting these “high-risk” donor grafts should be considered as a potential approach to reduce waiting list times and mortality while maintaining comparable post-transplant survival.
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01696A, PaperJing Huang, Anuradha Ramoji, Shuxia Guo, Thomas Bocklitz, Val érie Jahns, Jan Möller, Michael Kiehntopf, Michel Noutsias, Jürgen Popp, Ute Neugebauer Dilated cardiomyopathy (DCM) is a leading cardiomyopathy entity and is the leading reason for heart transplantation. Due to high etiologic and genetic heterogeneity of the pathologies, different therapeutic treatment strategies... The content of this RSS Feed (c) The Royal Society of Chemistry
This article discusses the basic science and clinical data that support the hypothesis that these changes pose pathophysiologic and potential novel therapeutic challenges.
Conclusions: The present study seeks to provide new insight in the pathophysiological mechanisms linking reduced kidney function to cardiovascular disease. In addition, we aim to enlighten predictors of adverse cardiovascular outcome in living kidney donors. The study is registered at Clinical-Trials.gov (identifier: NCT03729557). PMID: 31718316 [PubMed - as supplied by publisher]
' High survival benefit'centers are transplanting much sicker candidates and effectively saving more lives with the scarce resource than'low benefit'centers, researchers say.Medscape Medical News
Despite advances in treatment of idiopathic pulmonary arterial hypertension (IPAH), there remains no medical cure and patients can experience disease progression leading to right heart failure, progressive exercise intolerance and death. The reversed Potts shunt (left pulmonary artery to descending aorta) was re-introduced for treatment of end-stage IPAH to permit decompression of the suprasystemic right ventricle by right to left shunting, with preservation of upper body oxygenation. The shunt has the potential to delay the need for lung transplantation and offer a treatment for those who are transplant ineligible.
To develop a risk score to predict mortality or transplant in the interstage period.
We report on the prespecified secondary outcome, echocardiographic indexes of LV function, from a previously reported study of the effect of lung ultrasound (US)-guided dry weight reduction on systolic blood pressure.Study DesignSingle-blind randomized trial.Settings &Participants71 clinically euvolemic hypertensive hemodialysis patients in Greece and Slovenia.InterventionThe active intervention group’s (n = 35) volume removal was guided by the total number of lung US B-lines observed every week before a midweek dialysis session. The usual-care group (n = 36) was treated using standard-of-care...
Function Follows Form - A Review of Cardiac Cell Therapy. Circ J. 2019 Nov 13;: Authors: Nakamura K, Murry CE Abstract The investment of nearly 2 decades of clinical investigation into cardiac cell therapy has yet to change cardiovascular practice. Recent insights into the mechanism of cardiac regeneration help explain these results and provide important context in which we can develop next-generation therapies. Non-contractile cells such as bone marrow or adult heart derivatives neither engraft long-term nor induce new muscle formation. Correspondingly, these cells offer little functional benefit t...