Is PET really necessary to predict oncoming Alzheimer's?

Can a person's progression from mild cognitive impairment to Alzheimer's be...Read more on AuntMinnie.comRelated Reading: Study: FDG-PET reigns supreme for assessing Alzheimer's PET model tracks beta amyloid, Alzheimer's risk Florbetapir-PET links lack of financial acumen to dementia Flortaucipir-PET shows promise for detecting CTE Alzheimer's biomarkers could affect races differently
Source: Headlines - Category: Radiology Source Type: news

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In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice. To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the tr...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Although incurable, a staggering 40 per cent of cases could be prevented in the first place, according to a global report revealed at the Alzheimer's Association International Congress last week.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionsHowever, α‐MG (50 mg/kg) and XEFGM (100 mg/kg) reversed the cognitive impairment induced by CCH in MWM test. α‐MG (50 mg/kg) was further tested upon sub‐acute 14‐day treatment in CCH rats. Cognitive improvement was shown in MWM test but not in long‐term potentiation (LTP). BDNF but not CaMKII was found to be down‐regulated in CCH rats; however, both parameters were not affected by α‐MG. In conclusion, α‐MG ameliorated learning and memory deficits in both acute and sub‐acute treatments in CCH rats by improving the spatial learning but not hippocampal LTP. H...
Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Research Paper Source Type: research
CONCLUSIONS: Among older adults with dementia, proactive and ambulatory care that includes informal caregivers along with primary and specialty providers, may offer promise to decrease use and costs for chronic kidney disease, ischemic heart disease, atrial fibrillation, depression, and hypertension. PMID: 32729984 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
We examined whether the Hachinski Ischemic Scale (HIS) can predict dementia in elderly. METHODS: We leveraged data of the Canadian Study of Health and Aging. First, we examined the association of HIS with incident dementia. Next, we compared HIS to apolipoprotein E (APOE ɛ4) in prediction of dementia. We trained the HIS and APOE ɛ4 models in the training dataset and used the trained models for dementia prediction in the validation dataset. RESULTS: A higher HIS level was associated with a higher odds of dementia (odds ratio = 1.64, 95% confidence interval [CI]: 1.41 to 1.90, P 
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Authors: Wang Z, Tang Z, Zhu Y, Pettigrew C, Soldan A, Gross A, Albert M Abstract INTRODUCTION: Identifying cognitively normal individuals at high risk for progression to symptomatic Alzheimer's disease (AD) is critical for early intervention. METHODS: An AD risk score was derived using unsupervised machine learning. The score was developed using data from 226 cognitively normal individuals and included cerebrospinal fluid, magnetic resonance imaging, and cognitive measures, and validated in an independent cohort. RESULTS: Higher baseline AD progression risk scores (hazard ratio = 2.70, P
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
We present the results of the 5th CCCDTD, which convened in October 2019, to address topics chosen by the steering committee to reflect advances in the field, and build on previous guidelines. Topics included: (1) utility of the National Institute on Aging research framework for clinical Alzheimer's disease (AD) diagnosis; (2) updating diagnostic criteria for vascular cognitive impairment, and its management; (3) dementia case finding and detection; (4) neuroimaging and fluid biomarkers in diagnosis; (5) use of non-cognitive markers of dementia for better dementia detection; (6) risk reduction/prevention; (7) psychosocial ...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
FRIDAY, July 31, 2020 -- Older adults with both hearing and visual impairments -- dual sensory impairment (DSI) -- are at a significantly increased risk for dementia, according to a study published online July 7 in Alzheimer's&Dementia:...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
The present understanding of Alzheimer's disease is illustrative of a broader issue with aging in general, in that while there is considerable evidence to pin down specific pathological mechanisms in cells and tissues, it is hard to prove exactly how these mechanisms interact. What is cause, what is consequence. What is important, what is merely a side-effect of other, important processes. At present there is some upheaval in the Alzheimer's research community based on the failure of amyloid-β clearance to produce meaningful benefits in patients. This may or may not disrupt the present thinking on the condition, that ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Title: Under 50 and Overweight? Odds for Dementia IncreaseCategory: Health NewsCreated: 7/30/2020 12:00:00 AMLast Editorial Review: 7/31/2020 12:00:00 AM
Source: MedicineNet Alzheimer - Category: Geriatrics Source Type: news
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