Brain activation patterns associated with paragraph learning in persons with multiple sclerosis: The MEMREHAB trial

Publication date: Available online 20 October 2019Source: International Journal of PsychophysiologyAuthor(s): Olga Boukrina, Ekaterina Dobryakova, Veronica Schneider, John DeLuca, Nancy ChiaravallotiAbstractThe modified Story Memory Technique (mSMT) is a memory rehabilitation program that combines training in visualization and context formation to improve learning and memory. Previous studies have shown improvement in learning and memory in individuals with multiple sclerosis (MS) after undergoing the mSMT, including changes in brain activity related to working memory and word encoding. The current study examined changes in brain activity in 16 individuals diagnosed with MS (ntreatment = 6; nplacebo control = 10) when they were presented with to-be-remembered information within a meaningful context (i.e. a paragraph) from before to after mSMT treatment. We expected treatment-related changes in brain activation in the language network (LAN), default mode network (DMN), and executive control network (ECN). Consistent with this prediction, fMRI results revealed reduced brain activation in the LAN, DMN and ECN after completing the mSMT treatment in the context of paragraph learning. While no significant behavioral changes were observed, a marginally significant improvement with a large effect size was noted between baseline and follow-up performance on the Rivermead Behavioral Memory Test in persons who completed treatment. Results are discussed in terms of the impact of ...
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research

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Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Some studies have looked at the age at menarche and risk of Multiple Sclerosis (MS).We aimed to conduct a systematic review and meta-analysis to estimate a pooled odds ratio of developing MS by increasing age ...
Source: BMC Neurology - Category: Neurology Authors: Tags: Research article Source Type: research
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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Asthma and allergy Source Type: research
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Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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