GSK agrees €1bn sale of two vaccines

UK drugmaker offloads assets as it focuses on profitable and new products
Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news

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This study not only determined the primary reason for the atypical IBD epidemic, but also remind us of the urgency for developing new vaccines against novel variant IBDV.
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 15 November 2019Source: Veterinary MicrobiologyAuthor(s): Xian-Wei Wang, Mi Wang, Jing Zhan, Qian-Yu Liu, Lin-lin Fang, Chen-yao Zhao, Ping Jiang, Yu-Feng Li, Juan BaiAbstractSince late 2010, highly virulent PEDV G2-genotype strains have emerged globally extracting heavy losses on the pork industries of numerous countries. We investigated the characteristics of a field strain of PEDV (PEDV strain SH) isolated from a piglet with severe diarrhea on a farm in Shanghai China. Whole genome sequencing and analysis revealed that the SH strain belonged to subtype G2a and has a unique 12-aa deleti...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
In this study, we designed a simple strategy to achieve the co-delivery of a DNA vaccine and hydrophobic immune adjuvant (R848) and to enhance the adjuvanticity of R848 via the synergistic effect of GO and R848. Thiolated low-molecular-weight polyethylenimine (TPEI1.8) was crosslinked with 4-aminothiophenol-modified GO (TGO) via the formation of disulfide bonds. Thus, TGO with its assembled TPEI1.8 could not only load R848 but also electrostatically interact with the DNA vaccine. Owing to the reducibility of the disulfide bond in the cellular environment, the DNA vaccine could be readily released. This system can significa...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Publication date: 16 November 2019Source: New Scientist, Volume 244, Issue 3256Author(s): Sam WongA vaccine based on a weakened version of the dengue virus was 80 per cent effective at preventing infections after one year in a trial of 20,000 children
Source: New Scientist - Category: Science Source Type: research
[WHO] Juba, 15 November 2019 - To mitigate the risk of cholera outbreak, the World Health Organization (WHO) in collaboration with the Ministry of Health, UNICEF and MedAir are immunizing 144 033 people against cholera in Renk, a county bordering Blue Nile state in Sudan.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[WHO] Children in 19 Northern states to be vaccinated in largescale campaign implemented by the Government of Nigeria and WHO with Gavi support
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Gynecologic malignancies are among the most prevalent cancers affecting women worldwide, but they are heterogeneous diseases with varying risk factors, management paradigms, and outcomes. Gynecologic cancers mediated by human papillomavirus (HPV) are preventable and curable with early detection and treatment. Dramatic reductions in cervical cancer incidence and mortality have been achieved through cancer screening and HPV vaccination. Radiotherapy plays a central role in the management of gynecologic malignancies. For some cancers, radiotherapy alone can be curative. More often, radiotherapy is used in conjunction with sur...
Source: Hematology/Oncology Clinics of North America - Category: Cancer & Oncology Authors: Source Type: research
In conclusion, CASAC adjuvant has great potential to enhance immunogenicity elicited against HspX antigen, which could be an alternative regimen to improve the efficacy of future therapeutic vaccine against Mycobacterium tuberculosis.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
In this study we demonstrate that this vaccine provides, two weeks after vaccination, an additional protection (prevention of mortality, clinical signs, renal infection, bacterial excretion, renal carriage and renal lesions) against fatal leptospirosis due to Leptospira interrogans serovar Copenhageni (serovar of major medical importance).
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
This study aims to analyze the prevalence and to concentrate on the key risk factors that are responsible for hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infection in patients on HD visiting two dialysis centers in the city of Quetta in southwestern Pakistan. The overall incidence of HBV was found to be 16.1%, the overall incidence of HCV was found to be 43.2%, and two patients (1.6%) were found to be positive for both HBV and HCV. HIV was not found among patients seen at both hospitals during the study period. The main risk factors for development of a viral infection were the ...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
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