SPARC Expression in Desmoplastic and Non Desmoplastic Pancreatic Carcinoma and Cholangiocarcinoma

ConclusionsThe relevance of SPARC expression in pancreato-biliary carcinomas though may still be important for therapeutic decision making, it is not responsible for peritumoral stromal desmoplasia in these tumors and it does not have any significant prognostic implication.
Source: Pathology Research and Practice - Category: Pathology Source Type: research

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Despite histological evidence in various solid tumor entities, available experience with CXCR4-directed diagnostics and endoradiotherapy mainly focuses on hematologic diseases. With the goal of expanding the application of CXCR4 theranostics to solid tumors, we aimed to elucidate the feasibility of CXCR4-targeted imaging in a variety of such neoplasms. Methods: 19 patients with newly diagnosed, treatment-naïve solid tumors including pancreatic adenocarcinoma or neuroendocrine tumor, cholangiocarcinoma, hepatocellular carcinoma, renal cell carcinoma, ovarian cancer, and prostate cancer underwent [68Ga]Pentixafor PET/...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
For periampullary cancers, including adenocarcinoma of the pancreas, ampulla, bile duct, and duodenum, a curative-intent pancreaticoduodenectomy provides the only chance for long-term survival. Adjuvant systemic therapy has been conclusively shown to improve survival after surgery for pancreatic cancer, but there is far less convincing evidence regarding the benefit of adjuvant therapy for other periampullary cancers. This lack of evidence is because of several factors: the low incidence of nonpancreas periampullary cancers, difficulty determining their exact site of origin, and, for biliary tract cancers, the pooling toge...
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
Abstract OBJECTIVE: To study the relationship between the expression of SATB2 in colonic adenocarcinoma and clinicopathological factors, and its role in the identification of ovarian digestive system metastatic adenocarcinoma. METHODS: Immunohistochemistry was used to analyze the expression of SATB2 in 130 cases of colon adenocarcinoma, 46 cases of gastric adenocarcinoma, 47 cases of pancreatic ductal adenocarcinoma, 22 cases of cholangiocarcinoma, 53 cases of ovarian mucinous adenocarcinoma, and 38 cases of ovarian metastasis of colorectal carcinoma. Data was analyzed using SPSS 16.0 statistical software. ...
Source: Pathology, Research and Practice - Category: Pathology Authors: Tags: Pathol Res Pract Source Type: research
Conclusions Careful surveillance for second PDACs after curative treatment of BTCs and colorectal cancers should be considered.
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research
ConclusionsPDX models can be successfully created from clinical biopsy specimens in patients with metastatic or unresectable GI cancers. The use of clinical biopsy specimens for PDX engraftment can expand the repertoire of stage-specific PDX models for downstream basic/translational research.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
ConclusionsA series of studies provide detailed information to understand lncRNA AFAP1-AS1 role in various human cancers. LncRNA AFAP1-AS1 is an oncogene in tumors that have been studied so far, and it may act as a useful tumor biomarker and therapeutic target.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Abstract Circulating tumor cells (CTC) enter the blood from many carcinomas and represent a likely source of metastatic dissemination. In contrast to the peripheral circulation, KRAS mutation- positive CTC thrive in the portal venous blood of patients with pancreatic ductal adenocarcinoma (PDAC). To analyze the essential interactions that contribute to carcinoma CTC growth and immune resistance, portal venous blood was collected during pancreatico-duodenectomy in 41 patients with peri-ampullary pathologies (PDAC = 11; ampullary adenocarcinoma (AA) = 15; distal cholangiocarcinoma (CC) =&nbs...
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Tags: Cancer Biol Ther Source Type: research
Publication date: August 2018Source: Cancer Genetics, Volumes 224–225Author(s): Asmaa Mosbeh, Khalil Halfawy, Wael S. Abdel-Mageed, Dina Sweed, Mohamed H. Abdel-RahmanAbstractDeletion in the 3p21 region, the chromosomal location of BAP1, has been reported in a subset of hepatocellular carcinoma (HCC), biliary and pancreatic cancers. This suggests that BAP1 could play a role in the pathogenesis of these tumors. We assessed the frequency of BAP1 loss by immunohistochemistry in 103 hepatic, biliary and pancreatic cancers. We also assessed chromosomal alterations in the BAP1 region in the same tumors by genotyping. We id...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
This study set to examine relative survival of patients with periampullary cancers undergoing pancreaticoduodenectomy (PD).MethodsUsing the Surveillance, End Results and Epidemiology (SEER) database, this study identified 9877 patients with non-metastatic pancreatic adenocarcinoma who underwent PD between 2004 and 2013.ResultsAmpullary carcinomas have the best survival among periampullary malignancies. Lymph node ratio is a significant prognostic factor, even when stratified by tumour types. Patients receiving adjuvant radiotherapy following PD have superior survival than patients without radiotherapy (median 25 vs 20  months,p 
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Extrahepatic Bile Duct Adenocarcinoma, Biliary Type;   Gallbladder Adenocarcinoma, Biliary Type;   Metastatic Pancreatic Adenocarcinoma;   Recurrent Cholangiocarcinoma;   Recurrent Gallbladder Carcinoma;   Recurrent Hepatocellular Carcinoma;   Recurrent Intrahepatic Cholangioca rcinoma;   Recurrent Pancreatic Carcinoma;   Stage III Gallbladder Cancer AJCC V7;   Stage III Hepatocellular Carcinoma AJCC v7;   Stage III Intrahepati...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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