Minocycline induces the expression of intra-accumbal glutamate transporter-1 in the morphine-dependent rats.

Minocycline induces the expression of intra-accumbal glutamate transporter-1 in the morphine-dependent rats. Asian J Psychiatr. 2019 Oct 12;46:70-73 Authors: Arezoomandan R, Aliaghaei A, Khodagholi F, Haghparast A Abstract Glial glutamate transporters (GLT-1) is responsible for glutamate homeostasis. GLT-1 expression and glutamate uptake can be affected by addictive drugs and can be used as a target in addiction pharmacotherapy. It has been shown that minocycline, an antibiotic with anti-inflammatory, and neuroprotective properties, can upregulate the expression of GLT-1. In the present study, in morphine-dependent rats, the effect of minocycline on expression of GLT-1 in nucleus accumbens was investigated by immunohistochemistry. The expression of GLT-1 significantly increased in minocycline treated animals. In line with other studies, our findings showed that restoring GLT-1 expression with minocycline might be considered as a potential target for correcting pre-clinical and clinical manifestations of drug addiction. PMID: 31630007 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

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CONCLUSION: Dysregulated activity of EFhd2 is increasingly considered as a contributing factor for the development of numerous neurodegenerative disorders. Whether EFhd2 can be used as biomarker or in therapeutic approaches has to be addressed in future research. PMID: 31742960 [PubMed - in process]
Source: Neuro-Signals - Category: Neurology Authors: Tags: Neurosignals Source Type: research
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Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
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Source: The Rest of the Story: Tobacco News Analysis and Commentary - Category: Addiction Source Type: blogs
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Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
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