Minocycline induces the expression of intra-accumbal glutamate transporter-1 in the morphine-dependent rats.

Minocycline induces the expression of intra-accumbal glutamate transporter-1 in the morphine-dependent rats. Asian J Psychiatr. 2019 Oct 12;46:70-73 Authors: Arezoomandan R, Aliaghaei A, Khodagholi F, Haghparast A Abstract Glial glutamate transporters (GLT-1) is responsible for glutamate homeostasis. GLT-1 expression and glutamate uptake can be affected by addictive drugs and can be used as a target in addiction pharmacotherapy. It has been shown that minocycline, an antibiotic with anti-inflammatory, and neuroprotective properties, can upregulate the expression of GLT-1. In the present study, in morphine-dependent rats, the effect of minocycline on expression of GLT-1 in nucleus accumbens was investigated by immunohistochemistry. The expression of GLT-1 significantly increased in minocycline treated animals. In line with other studies, our findings showed that restoring GLT-1 expression with minocycline might be considered as a potential target for correcting pre-clinical and clinical manifestations of drug addiction. PMID: 31630007 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research