Defining the Genetics of Basosquamous Carcinoma

Basosquamous carcinoma (BSC) is a rare form of skin cancer with both basaloid and squamous morphology. Chiang et  al. (2019) genetically define BSCs and demonstrate that BSCs likely originate as basal cell carcinomas that partially squamatize through accumulation of ARID1A mutations and RAS/MAPK pathway activation.

Source: Journal of Investigative Dermatology - October 21, 2019 Category: Dermatology Authors: Eric Tarapore, Scott X. Atwood Tags: Commentary Source Type: research