The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment

Glioblastoma is the most common and aggressive brain tumour in adults with a median overall survival of only 14  months after standard therapy with radiation therapy (IR) and temozolomide (TMZ). In a novel mult...
Source: Journal of Experimental and Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Research Source Type: research

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ConclusionAlthoughmost brain tumors are metastases, primary brain tumors should be considered a possibility even in the presence of another source of metastases; especially if there is a lesion refractory to treatment.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
This study examines associations found between incidence of brain tumor and ethnicity.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
Authors: Shimazaki S, Kazukawa I, Mori K, Kihara M, Minagawa M Abstract We retrospectively analyzed endocrine late effects in 81 childhood cancer survivor (CCS) patients who had been referred to our endocrinology department in Chiba Children's Hospital between January 1, 2008 and December 31, 2016. Among 69 eligible patients (33 male, 36 female), endocrine late effects were identified in 56 patients (81.1%). The median age at the last visit to our endocrinology department was 17.4 years (range: 7.1-35.3 years). The most common primary cancer was acute lymphoblastic leukemia (22 patients, 31.8%). Forty-four patients...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
A radiation therapy (RT) treatment that combines radiation with chemotherapy...Read more on AuntMinnie.comRelated Reading: Intelerad to launch enterprise software at RANZCR 2019 RANZCR issues final version of ethical AI guidelines RANZCR praises government pledge to support MRI access RANZCR proposes ethical guidelines for AI Virtual reality may help plan, guide glioma resection
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
A radiation therapy (RT) treatment that combines radiation with chemotherapy...Read more on AuntMinnie.comRelated Reading: Intelerad to launch enterprise software at RANZCR 2019 RANZCR issues final version of ethical AI guidelines RANZCR praises government pledge to support MRI access RANZCR proposes ethical guidelines for AI Virtual reality may help plan, guide glioma resection
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
We investigated by immunohistochemistry the clinical significance and the evolution of Oligodendrocyte lineage transcription factor 2 (OLIG2) and cyclin D2 (CCND2) protein expression, two markers highly specific of glioma stem cells, on a cohort of human paired glioblastoma samples comparing initial resections with recurrent tumors after radiation therapy alone or radio ‐chemotherapy with temozolomide according to the Stupp regimen. Our study highlighted for the first time the prognostic value of high nuclear expression of CCND2 at initial surgery which is associated with early mortality and patients for whom nuclear exp...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
ConclusionsCoverage guidelines for IMRT, SRS, SABR, and PBT vary across 5 major insurance providers and may be substantially discordant compared with ASTRO coverage guidelines. There remain several specific areas where ongoing and future dialogues between ASTRO members, payers, and policymakers remain essential.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
ROCHESTER, Minn. -- Mayo Clinic physicians will present findings at the American Society for Therapeutic Radiology and Oncology annual meeting Sept. 15-18 in Chicago. Key Mayo Clinic-led studies include: Prolonged radiation therapy does not improve brain tumor control Embargoed until Sunday, Sept. 15, at 1 p.m. CDT Prolonged radiation therapy for brain cancer patients does [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
We present an open-source WMPL tool, implemented in the package Diffusion Imaging in Python (DIPY), and code to convert the resulting WMPL map to anisotropic contours for RT in a commercial treatment planning system.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: Polymorphisms involved in cell cycle, telomere protection and stability and DNA repair are not associated with gliomas. On the other hand, alcohol consumption and SAH stand out as independent risk factors for the disease. Low-grade gliomas, response to treatment and the combination of chemotherapy with Temozolomide and radiation therapy show increased survival of patients. PMID: 31450905 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
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