Cutibacterium acnes Type II strains are associated with acne in Chinese patients.

Cutibacterium acnes Type II strains are associated with acne in Chinese patients. Antonie Van Leeuwenhoek. 2019 Oct 19;: Authors: Zhao S, Ci J, Xue J, Wang Y, Li X, Hao L, Tian L, Guo H, Xin C, Zhao Y Abstract Acne is a common inflammatory skin disease, especially in adolescents. Certain Cutibacterium acnes subtypes are associated with acne, although more than one subtype of C. acnes strains may simultaneously reside on the surface of the skin of an individual. To better understand the relationship between the genomic characteristics of C. acnes subtypes and acnes, we collected 50 C. acnes strains from the facial skin of 10 people (5 healthy individuals, 5 patients with acne) in Liaoning, China and performed whole genome sequencing of all strains. We demonstrated that the six potential pathogenic C. acnes strains were all Type II subtype, and discovered 90 unique genes of the six strains related to acne using pan-genome analysis. The distribution of 2 of the 90 genes was identified by PCR in bacterial cultures collected from the facial skin of 171 individuals (55 healthy individuals, 52 patients with mild acne and 64 patients with moderate to severe acne). Both the genes were significantly associated with acne (Chi square test, P < 0.01). We conclude that Type II strains are associated with acne in Chinese patients. PMID: 31630297 [PubMed - as supplied by publisher]
Source: Antonie van Leeuwenhoek - Category: Microbiology Authors: Tags: Antonie Van Leeuwenhoek Source Type: research