Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates

Translational Psychiatry, Published online: 21 October 2019; doi:10.1038/s41398-019-0608-1Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates
Source: Translational Psychiatry - Category: Psychiatry Authors: Source Type: research

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Publication date: Available online 25 January 2020Source: NeuroImageAuthor(s): Thomas A.W. Bolton, Lorena Freitas, Delphine Jochaut, Anne-Lise Giraud, Dimitri Van De VilleAbstractNaturalistic movie paradigms are exquisitely dynamic by nature, yet dedicated analytical methods typically remain static. Here, we deployed a dynamic inter-subject functional correlation (ISFC) analysis to study movie-driven functional brain changes in a population of male young adults diagnosed with autism spectrum disorder (ASD). We took inspiration from the resting-state research field in generating a set of whole-brain ISFC states expressed by...
Source: NeuroImage - Category: Neuroscience Source Type: research
ConclusionThe DRA provides crucial information about levels of and desire for autonomy that can be used to promote participation of adolescents with ASD in setting their own goals for independent living.
Source: Journal of Adolescence - Category: Child Development Source Type: research
ConclusionsPractitioners should consider use of less restrictive or intrusive interventions to promote food acceptance and the use of larger sets of foods, modified to include fewer foods in the case of poor response to intervention.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
This study explored the relationship between the two disorders by collecting extensively validated measures of autistic trait burden (Social Responsive Scale, Second Edition) and schizoid PD affectation (Diagnostic Interview for Genetic Studies) from clinically ascertained verbal males with and without autism ages 12 to 25 years (N = 72) via parent, teacher, and self-report. Although only a small minority of adolescents with ASD met full diagnostic criteria for schizoid PD, participants with ASD endorsed a continuous distribution of schizoid PD traits that reflected a pronounced pathological shift in comparison with those ...
Source: The Journal of Nervous and Mental Disease - Category: Psychiatry Tags: Original Articles Source Type: research
We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n = 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to integrate de novo and case-control rare variation, we identify 102 risk genes at a false discovery rate of 0.1 or less. Of these genes, 49 show higher frequencies of disruptive de novo variants in individuals ascertained to have severe neurodevelopmental delay, whereas 53 show higher frequencies in individuals ascertained to have ASD; comparing ASD cases with mutations in these groups reveals phenotypic differences. Expressed early in brain devel...
Source: Cell - Category: Cytology Source Type: research
In conclusion, the analyses on simulated and real EEG data demonstrate that staNMF can be used to characterize dynamic functional networks, making it a promising tool for investigating disorders using resting-state EEG.
Source: Neurocomputing - Category: Neuroscience Source Type: research
This article discusses how existing legal and social constructs may exacerbate rather than diminish barriers and access for autistic adults and identifies current and potential legal and policy solutions to reducing current systemic barriers. This article ultimately supports a supported decision-making model for autistic adolescents transitioning into adulthood.
Source: Child and Adolescent Psychiatric Clinics of North America - Category: Psychiatry Authors: Source Type: research
Autism spectrum disorder is a complex neurodevelopmental condition that is likely caused by both genetic and environmental factors. As the name suggests, it also represents a range of symptoms and behaviors, all of which makes teasing apart the genes involved quite challenging. In a study published Jan. 23 in Cell, researchers led by Joseph Buxbaum, director of the Seaver Autism Center for Research and Treatment at Mount Sinai, took advantage of better genetic sequencing technologies and one of the largest databases of DNA samples from people with autism to identify 102 genes associated with autism, including 30 that had n...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Autism Brain Genetics Source Type: news
In this study, we investigated the effect of 5-AIQ on sociability tests, self-grooming, marble burying, and locomotor activities in BTBR T+ Itpr3tf/J (BTBR) mice, which serve as an ASD animal model. We further investigated the possible molecular mechanism of 5-AIQ administration on CXCR4-, CXCR6-, IFN-γ-, IL-22-, NOS2-, STAT1-, T-bet-, and RORγT-producing CD3+ T cells isolated from the spleens of treated mice. We also explored its effects on mRNA expression in brain tissue. Our results showed that in BTBR mice, 5-AIQ treatment significantly prevented self-grooming and marble burying behaviors and enhanced socia...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
(Natural News) Gastrointestinal (GI) problems have always been a common occurrence in many patients with autism, yet the mechanisms behind this phenomenon are not fully understood. Studies have shown that around 70 percent of people with autism spectrum disorder (ASD) have a variant of gastrointestinal disorder, including gastroesophageal reflux disease (GERD) and gastritis. If left...
Source: - Category: Consumer Health News Source Type: news
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