IL-17A contributes to propagation of inflammation but does not impair adipogenesis and/or insulin response, in adipose tissue of obese individuals.

CONCLUSION: we show herein that IL-17A does not play a major role in the impairment of adipogenesis and/or insulin resistance mediated by an inflammatory environment, but contributes to the propagation of inflammation in human obese adipose tissues. This suggests a beneficial effect of anti-IL17A mAb in inflammatory pathologies, where obesity contributes to poorer response to biologic treatments.
PMID: 31629101 [PubMed - as supplied by publisher]

Source: Cytokine - October 15, 2019 Category: Molecular Biology Authors: Pestel J, Chehimi M, Bonhomme M, Robert M, Vidal H, Eljaafari A Tags: Cytokine Source Type: research