Comprehensive identification of steroid hormones in human urine based on liquid chromatography-high resolution mass spectrometry.

Comprehensive identification of steroid hormones in human urine based on liquid chromatography-high resolution mass spectrometry. Anal Chim Acta. 2019 Dec 16;1089:100-107 Authors: Zheng Y, Zhao H, Zhu L, Cai Z Abstract Steroid hormones, structural derivatives of cyclopentanoperhydrophenanthrene, play important roles in modulation of many physiological processes. Comprehensive characterization of steroid hormones is valuable for understanding the process of human life activities and even disease diagnosis. Hitherto systematical characterization of steroid hormones has been rarely investigated. Here, we presented an integrated method for human urine analysis based on ultra-high performance liquid chromatography-high resolution mass spectrometry in data-dependent acquisition mode with the following parallel reaction monitoring mode. To process the data acquired by two scan modes, a comparative study of standards' fragmentation behaviors and diagnostic product ions (DPIs) were firstly conducted to facilitate the characterization of steroid hormones. The fragmentation behaviors, DPIs, elemental composition and double-bond equivalent were then simultaneously utilized for systematical characterization of steroid hormones in human urine. Consequently, fragmentation pathways and DPIs for all types of steroid hormones were comprehensively interpreted. It is interesting to find that dehydration is not restricted in the form of hydroxyl groups loss, elimination of t...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research

Related Links:

Artificial intelligence is already widely entrenched in healthcare industry, so the question should not be, "Will AI happen or not?" said David Houlding, CISSP, CIPP, principal healthcare lead, at Microsoft, in an interview with MD+DI. “It's very much 'What tasks will AI help with, and what will it do and what will it not do?’ ” he continued. “I think we're still learning some of that, but it's largely a proven technology, not just for healthcare providers but for payers, for pharmaceuticals, for life sciencesâ&#...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Source Type: news
CONCLUSIONS The nude mouse orthotopic liver transplantation model of human HCC was shown to be a reliable model that has the potential for future research on the pathogenesis and progression of HCC and studies on drug development. PMID: 31736477 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Marques B, Couto J, Lemos MC, Rodrigues F Abstract Juxtaglomerular tumours are rare causes of secondary hypertension. They typically present with difficult-to-manage hypertension, hypokalemia, hyperreninemia and secondary hyperaldosteronism. The authors describe a clinical case of a 45 years old female patient, with personal history of difficult-to-manage hypertension and hypokalemia since age 35, medicated with four types of anti-hypertensive agents. An analytical study was performed, which revealed secondary hyperaldosteronism [aldosterone 44.3 ng/dL (4 - 28 ng/dL), renin> 1000 mIU/mL (4.4 - 46.2 mIU/...
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
Researchers at San Diego State University are developing a glassy carbon electrode...Read more on AuntMinnie.comRelated Reading: MEG helmet enables 3D functional brain imaging in kids 7T MRI opens door to detailed brain images 3T MRI feasible for deep brain stimulation patients Stretchable MRI coils on the horizon for MSK imaging Novel MRI scanner fits extremity imaging like a glove
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: Available online 19 November 2019Source: Materials Today: ProceedingsAuthor(s): B. Nageswara Rao, N. SatyanarayanaAbstractSamarium oxide (Sm2O3) coated LiCoO2 particles were synthesized using resin coating process. The prepared samples were subjected to characterization using thermogravimetry analysis (TGA)/differential scanning calorimetry (DSC), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and cyclic voltammetry (CV) techniques. The formation of phase pure LiCoO2 was confirmed from XRD studies. No diffraction peak was observed for Sm2O3 phas...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 20 November 2019Source: Materials Science and Engineering: CAuthor(s): Yingchun Liu, Chenfang Xu, Xiaoshan Fan, Xian Jun Loh, Yun-Long Wu, Zibiao LiAbstractMultifunctional mixed micelles possessing targeting folates on the periphery and stable radicals in the core were prepared from the mixture of folate-poly(ethylene glycol)-block-poly(d-lactide) (FA-PEG-b-PDLA) and poly(ethylene glycol) methyl ether-block-poly(l-lactide)- 2,2,6,6-tetramethylpiperidine-1-oxyl (mPEG-b-PLLA-TEMPO). FA-PEG-b-PDLA and mPEG-b-PLLA-TEMPO were prepared by combining ring-opening polymerization (ROP) of lactide w...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 19 November 2019Source: Journal of Membrane ScienceAuthor(s): Yixia Zhai, Xingran Zhang, Zhichao Wu, Zhiwei WangAbstractMembrane biofouling is one of major issues impeding the applications of polyvinylidene fluoride (PVDF) membrane for water and wastewater treatment. In this work, quaternary ammonium compounds loaded on silica nanopollens (QAC@SNP) were developed to modify polyvinylidene fluoride (PVDF) membrane for mitigating biofouling. The modified membrane (M-Si-Q) by QAC@SNP demonstrated efficient antibacterial efficiency against E. coli (inhibition rate ∼98.2%) and S. aureus (in...
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
Publication date: Available online 19 November 2019Source: Sensors and Actuators A: PhysicalAuthor(s): Aditya Rianjanu, Kuwat Triyana, Doni B. Nugroho, Ahmad Kusumaatmaja, Roto RotoAbstractAnalytical parameters including sensitivity in the QCM sensing system are critical to understand its sensing mechanism. We investigated the QCM analytical parameters after the QCM electrode surface was modified with polyvinyl acetate (PVAc) nanofiber for primary alcohols’ vapor detection. The PVAc nanofibers were prepared by electrospinning method and were observed using a scanning electron microscope (SEM). The modified QCM sensin...
Source: Sensors and Actuators A: Physical - Category: Physics Source Type: research
Publication date: Available online 19 November 2019Source: Carbohydrate PolymersAuthor(s): Chao Ling, Lamei GuoAbstractA novel formaldehyde-free and halogen-free flame retardant (FR), HBPOPN, was synthesized under solvent-free conditions and applied on cotton fabric to improve its durability. The reactive groups of HBPOPN could react with cellulose to form covalent bonds. The limit oxygen index (LOI) value of 160 g/L HBPOPN-treated cotton was 42.0% and the LOI value was still 29.3% after 50 laundering cycles (LCs). The entire vertical flammability test showed no after-flame or after-glow time. Moreover, the cone calorimetr...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
AbstractPurpose of ReviewPositron emission tomography (PET) combined with computed tomography (CT) has proven useful as a cancer screening technique in patients with inflammatory myopathy, mainly dermatomyositis. In this review, we focus on advances in this direction and other potential applications of PET/CT in patients with inflammatory myopathy.Recent FindingsCancer screening by PET/CT seems suitable and cost-effective in patients with myositis. It has also shown value as a hybrid technique for diagnosing myositis versus controls and could be of interest for differentiating between polymyositis and sporadic inclusion bo...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
More News: Chemistry | Hormones | PET Scan | Study