MISC 14. Elevated Circulating Tissue Inhibitor of Metalloproteinase 1 in Patients With Chronic Obstructive Pulmonary Disease Combined With Pulmonary Hypertension

This study was designed to investigate whether angiogenesis factors could serve as noninvasive markers for the diagnosis of PH in the COPD patient and which could serve as therapeutic targets.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research

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We present a case study and a review and discussion of the pertinent literature on this topic. PMID: 31382489 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Authors: Ewert R, Heine A, Bollmann T, Müller-Heinrich A, Gläser S, Opitz CF Abstract While right heart catheterization (RHC) at rest is the gold standard to assess pulmonary hemodynamics in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH), the invasive measurement of exercise hemodynamics is less well established in this group. Since exercise hemodynamics are increasingly recognized as important clinical information in patients with PH, our goal was to review the literature in this field to provide a basis for clinical use, further studies, and future recommendat...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
Background: Pulmonary hypertension (PH) is often associated with respiratory diseases (R-PH), but pulmonary arterial hypertension (PAH)-specific therapy has not been approved for R-PH. We previously showed an improved survival in patients who received phospphodiesrerase-5 inhibitors for severe R-PH patients.Aim: To evaluate the demographics, survival and prognoses of R-PH patients in pulmonary specialized centers in Japan.Methods: We prospectively registered R-PH patients with confirmed mean pulmonary arterial pressure (PAP) ≥25mmHg by right heart catheterization from 21 participating pulmonary specialty centers between...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary hypertension Source Type: research
Conclusion: Sildenafil was well tolerated in patients with severe group 3 PH, with improved WHO FC, BNP and quality of life, and a good safety signal. Larger studies are warranted.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary hypertension Source Type: research
Conclusions: In COPD patients, CT measurements that reflect the small pulmonary vessels may predict pulmonary hypertension.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Imaging Source Type: research
Aim: Novel therapies exist for severe asthma. We analyzed asthma features in patients with severe COPD to identify potential therapy candidates.Method: We undertook a cross-sectional analysis of 80 consecutive patients with severe COPD, GOLD IV/D (ex-smokers of>6 months, pack years 36±21). Patients were examined for history of allergy, asthma, exacerbation rate, lung function tests, 6-minute walk test, skin prick test, fractional exhaled nitric oxide (FENO), normal and induced sputum, differential blood count and serum immunoglobulin. Right-heart catheterisation and chest CT were carried out.Results: 80 patients ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
CONCLUSIONS: The use of echocardiographic criteria for the presence of PH is adequate for the screening of COPD patients. Patients with acute exacerbation of COPD and possible/likely PH demonstrate worse mortality compared to patients unlikely to have PH. PMID: 29471029 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Cardiology - Category: Cardiology Tags: Hellenic J Cardiol Source Type: research
Purpose of review Pulmonary hypertension is common (25–90%) in chronic obstructive pulmonary diseases (COPDs). Severe pulmonary hypertension, however, is quite rare (1–3%). The term ‘out of proportion’ pulmonary hypertension is still widely used. New guidelines instead propose to use the term ‘Severe pulmonary hypertension’ if mean pulmonary arterial pressure at least 35 mmHg or cardiac index (CI) is less than 2.0 l/min/m2 on right heart catheterization (RHC). Why only a minority of COPD patients develop severe pulmonary hypertension is unclear. Recent findings When present, sever...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: OBSTRUCTIVE, OCCUPATIONAL AND ENVIRONMENTAL DISEASES: Edited by Manish Joshi and Basil Varkey Source Type: research
Conclusion 1-Pulmonary hypertension is a common sequel in COPD patients mostly with moderate severity, and is mainly of mild degree of PH. 2-Small proportion of COPD patients could develop PH disproportionate to the degree of airway obstruction which termed as out of proportion PH. 3-ECHO and even RHC are of crucial importance in detection of PH in patients with COPD in order not to miss cases with out of proportion PH.
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
Conclusions: these limited preliminary data seem to suggest that randomized long-term trials with specific drugs are needed in group 3 PH, preferentially addressing patients with severe PH associated to COPD/E.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research
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