Polymicrogyria : MRI Teaching Case

Discussion -Polymicrogyria is one of the most common malformations of cortical developmentin which the process of normal cerebral cortical development is disturbed late in the stage of neuronal migration or early in the stage of cortical organization, thus considered a disorder of neuronal organization.1. Causes - Congenital infection (particularly cytomegalovirus infection).              - Localized or diffuse in utero ischemia.              - Mutations.2. Clinical profile - ranging from hemiparesis or partial epilepsy to developmental delay, quadriparesis, medically refractory, intractable epilepsy.3. Associations – can be isolated malformation or it may be associated with other brain malformations like corpus callosum agenesis and hypogenesis, cerebellar hypoplasia, periventricular nodular heterotopias and subcortical heterotopias.4. The imaging appearance of polymicrogyria is variable which can be due to-    imaging factors (amount of gray matter–white matter contrast, thickness of the slices).-    the stage of maturity/ myelination of the brain at the time of the imaging study.-    the type of PMG.4a. Types of polymicrogyria -- Multiple small delicate gyri.- Thick and irregularly bumpy or be paradoxically smooth because the outer cortical (molecular) layer fuse...

Source: Sumer's Radiology Site - October 19, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs