What Doesn ’t Kill You Makes You — Different

“And once the storm is over, you won’t remember how you made it through, how you managed to survive. You won’t even be sure whether the storm is really over. But one thing is certain. When you come out of the storm, you won’t be the same person who walked in. That’s what this storm’s all about.” — Haruki Murakami “People keep telling me what doesn’t kill me will make me stronger. I’ve come to hate that phrase.” Janie B. has been going through a tough time. She is overseeing the care of her elderly mother who has Alzheimer’s. Her husband lost his job, throwing them into financial difficulty. And Janie herself has had some health issues. Friends and family mean well. That chestnut of a phrase about finding strength through adversity is intended to encourage her. Instead it has become an annoyance and, worse for Janie, a pressure. “I mean, what if I don’t get stronger? What if I just manage to keep going? Isn’t that enough?” Janie has a point. It’s hard for people who are in the midst of a traumatic experience or  cascade of life’s challenges to get on board with the idea that it will toughen them up. Why should they? It’s hard enough to get through the day without feeling like a failure if they don’t feel strengthened by the process. Let’s give ourselves and others a break; we may or may not become “stronger.” It’s enough to ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Grief and Loss Motivation and Inspiration Self-Help Coping Skills grieving personal loss Resilience Source Type: blogs

Related Links:

In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice. Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and contro...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
TIME held its first TIME 100 Health Summit on Thursday aiming to define — and shape — the future of health care. The Summit, which is an offshoot of the magazine’s annual TIME 100 list of influential people, featured scientists, politicians and entertainers, such as former President Bill Clinton, former Vice President Al Gore, NIH Director Dr. Francis Collins, actress Selma Blair, NBA commissioner Adam Silver, comedian Tig Notaro and former Planned Parenthood President Dr. Leana Wen. The day included a range of interviews, panels and performances. Here are the biggest moments from the Summit. Former Vice ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Comedy HealthSummit19 onetime Source Type: news
ConclusionsRisk of Alzehimer ’s-related mortality increases significantly among survivors of head and neck cancers and brain cancers. Further studies shall address the biological risk-modifying effects of aging, gender, and treatment.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
This study, as well as other research on the connection between diet and sugary beverages and health risks, is observational and cannot show cause and effect. That’s a major limitation, researchers say, as it’s impossible to determine whether the association is due to a specific artificial sweetener, a type of beverage, obesity or another hidden health issue. “The cause behind these associations isn’t clear,” said Bergquist. “Other potential biological causes could be attributed to experimental evidence linking consumption of artificial sweeteners to sugar cravings, appetite stimulation ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Soda Source Type: news
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Lanabecestat is a human β-site amyloid precursor protein-cleaving enzyme 1 inhibitor in development to slow disease progression in patients with early Alzheimer's disease. The study evaluated the breast cancer resistance protein (BCRP) inhibition potential of lanabecestat on the pharmacokinetics (PK) of rosuvastatin, a probe for BCRP activity, in healthy white subjects who were not carriers of SLCO1B1 (c.521T>C), not homozygotes for ABCG2 (c.421C>A or c.34G>A), and not heterozygotes of ABCG2 (c.421C>A and c.34G>A). The safety of lanabecestat + rosuvastatin, the effects of rosuvastatin ...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Pharmacol Source Type: research
In this study we report the contribution and prognostic significance of GSK3B to two breast cancer subtypes; ductal carcinoma in-situ (DCIS) and invasive ductal carcinoma (IDC) using the Oncomine platform. We performed high throughput screening using molecular docking. We identified BT-000775, a compound that was subjected to further computational hit optimization protocols. Through computational predictions, BT-000775 is a highly selective GSK3B inhibitor, with superior binding affinity and robust ADME profiles suitable for the patho-physiological presentations. PMID: 31354196 [PubMed]
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
ConclusionsResults indicate that chemotherapy-induced spatial memory deficits in mice can be prevented, but not reversed by the use of acetylcholinesterase inhibitors concomitant with chemotherapy, suggesting that these agents should be investigated further for the prevention of chemobrain.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
(Natural News) Alzheimer’s disease might not strike fear in your mind the way cancer does, but it kills more people than prostate and breast cancer combined. It has become an epidemic, and scientists are still trying to decipher the exact mechanisms of the disease. One thing that is becoming increasingly apparent, however, is the role...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Imagine a country where citizens will have their genetic profiles integrated into the digital health system with individual risk scores and pharmacogenomic information, so when they go to the doctor, they will get fully personalized, genetic risk-based diagnosis, medication, and preventive measures. That’s where healthcare in Estonia will arrive soon. They started to build their digital health system 20 years ago, and within the next years, the Baltic country will start to reap the benefits of a transparent, blockchain-based, digital health system hooked on genetic data. The first fully digitized republic certainly s...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Healthcare Policy analysis digital digital democracy digital health digital health strategy digital health system digital healthcare Estonia genetics genomics personalized Personalized medicine pharmacogenomi Source Type: blogs
More News: Alzheimer's | Breast Cancer | Cancer | Cancer & Oncology | Psychology