Polycaprolactone nanofiber mats decorated with photoresponsive nanogels and silver nanoparticles: Slow release for antibacterial control

Publication date: Available online 19 October 2019Source: Materials Science and Engineering: CAuthor(s): Camilo A.S. Ballesteros, Daniel S. Correa, Valtencir ZucolottoAbstractSmart nanomaterials activated by light is one of the most exciting strategies to control the release of substances in varied environments. Here we developed a smart nanomaterial formed by a photoresponsive nanogel containing silver nanoparticles (AgNPs) immobilized on the surface of biodegradable polycaprolactone (PCL) nanofibers mats produced by electrospinning. The silver nanoparticles (AgNps) are released from the nanogel and dispersed inside the nanofiber mats when this system is irradiated by light at 405 nm. This light excites the plasmonic band of the silver nanoparticles, which breaks the nanogel and, as a consequence, releases the AgNps in the nanofibers. Consequently, this AgNps release mechanism controls the propagation of silver ions by the application of light. Different configurations of antibacterial nanofibers mats, including neat PCL nanofibers and PCL nanofibers modified with AgNps-Nanogels and AgNps excited by laser light at 405 nm were investigated regarding antibacterial properties. The best result was achieved using PCL nanofiber mats functionalized with AgNps and AgNps-Nanogels after light exposure, which generated inhibition diameter of 2.6 ± 0.3 mm and 1.8 ± 0.5 mm for S. aureus and E. coli, respectively. The smart nanomaterial developed here is a pr...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research

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De‑O‑acylated lipooligosaccharide of E. coli B reduces the number of metastatic foci via downregulation of myeloid cell activity. Oncol Rep. 2019 Nov 08;: Authors: Mierzejewska J, Szczygieł A, Anger-Góra N, Rossowska J, Jarosz J, Wietrzyk J, Kaszowska M, Maciejewska A, Jachymek W, Niedziela T, Lukasiewicz J, Lugowski C, Boratyński J, Pajtasz-Piasecka E Abstract Lipopolysaccharides are the main surface antigens and virulence factors of gram‑negative bacteria. Removal of four ester‑bound fatty acid residues from hexaacyl lipid A of Escherichia coli lipooligosaccharide (LOS...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
In this study, 6-deoxy-6-arginine modified chitosan (DAC), was synthesized and characterized by Fourier Transform Infrared Spectroscopy (FTIR), 1H and 13C nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC) and elemental analysis. The arginine was grafted onto C6 groups of chitosan. Antibacterial activity of DAC against gram-negative bacteria Escherichia coli (E. coli) and gram-positive bacteria Staphylococcus aureus (S. aureus) were investigated at concentration between 0.02 mg/mL and 10 mg/mL. Cell viability assessment was estimated in vitro with Caco-2 and L929 cells. Water solubility...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
In conclusion, we generally found low ESBL/AmpC/Carbapenemase prevalence in E. coli strains isolated in Northern/Eastern Europe. However, several inter-country differences in distribution of particular genes and multilocus sequence types were found.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Treatment of multi-drug resistant (MDR) Escherichia coli intestinal infections are being hampered by the presence of the mcr-1 (colistin) and tet (tetracycline) resistance genes in these strains. We screened seven traditional Chinese medicines for their ability to synergize with tetracycline to provide an effective new drug for the treatment of animal intestinal diseases caused by MDR E. coli. Our primary screen identified quercetin as a compound that reduced the minimum inhibitory concentration (MIC) of tetracycline against the E. coli standard test strain American Type Culture Collection (ATCC) 25922 and clinical isolate...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
DiscussionRoutine hygienic maintenance of the PTS makes pathogen transmission by PTS highly unlikely, although entry racks should be regularly disinfected. Any involvement of the PTS in our VRE outbreak was also unlikely.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Health officials are investigating whether Ready Pac Bistro Chicken Caesar Salad is linked to an E. coli outbreak that has sickened 17 people across 8 states, and has hospitalized seven so far.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: March 2020Source: Materials Science and Engineering: C, Volume 108Author(s): Xiaolin Nie, Shuanglin Wu, Alfred Mensah, Keyu Lu, Qufu WeiAbstractFaced with the emergence and proliferation of antibiotic resistant pathogens, novel nonspecific materials and approaches are required. Herein, we employed electrospinning technology to fabricate nanofibers with antibacterial photodynamic inactivation. This material combines polyacrylonitrile, as a photostable polymer, and biocompatible carbon quantum dots. The resulted nanofibers were successfully characterized by physical and spectroscopic methods. The microbicid...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: March 2020Source: Materials Science and Engineering: C, Volume 108Author(s): Gul Afreen, Mohd Shoeb, Sreedevi UpadhyayulaAbstractThe present study investigates the role of reactive oxygen species (ROS) generated on surface of nanophotocatalyst in wastewater treatment discharged from exponentially growing industries. A facile synthetic route is presented to produce reduced graphene oxide/CdS quantum dot (rGO/CdS QD) heterostructure by monowave-assisted solvothermal method where room temperature ionic liquid 1-ethyl-3-methylimidazolium thiocyanate serves as a “green” precursor. The prepared phot...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 21 November 2019Source: Food Research InternationalAuthor(s): Xiaojing Tian, Yi Liu, Qianqian Yu, Lele Shao, Xingmin Li, Ruitong DaiAbstractTo investigate the inactivation mechanism of ohmic heating (OH) on Escherichia coli O157:H7 at the same inactivation levels, a label-free quantitative proteomic approach was employed in this study. Quantification of 2633 proteins was obtained with high confidence. Compared to untreated samples (CT), a total of 169, 84, and 26 proteins showed significantly differential abundance after high voltage OH (HVOH, 10 V/cm), low voltage OH (LVOH, 5 V/cm), and ...
Source: Food Research International - Category: Food Science Source Type: research
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