Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases.

This article reviews the evidence for environmental modulation of gut microbiota and its relevance to brain disorders, exploring in particular the implications for neurodegenerative diseases. We will focus on three major environmental factors that are known to influence the onset and progression of those diseases, namely exercise, diet and stress. Further exploration of environmental modulation, acting via both peripheral (e.g. gut microbiota and associated metabolic dysfunction or 'metabolopathy') and central (e.g. direct effects on CNS neurons and glia) mechanisms, may lead to the development of novel therapeutic approaches, such as enviromimetics, for a wide range of neurological and psychiatric disorders. PMID: 31628992 [PubMed - as supplied by publisher]
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research

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Publication date: Available online 9 December 2019Source: NeuroImageAuthor(s): Robert A. Brown, Dumitru Fetco, Robert Fratila, Giulia Fadda, Shangge Jiang, Nuha M. Alkhawajah, E. Ann Yeh, Brenda Banwell, Amit Bar-Or, Douglas L. Arnold, Canadian Pediatric Demyelinating Disease NetworkAbstractIn conventional non-quantitative magnetic resonance imaging, image contrast is consistent within images, but absolute intensity can vary arbitrarily between scans. For quantitative analysis of intensity data, images are typically normalized to a consistent reference. The most convenient reference is a tissue that is always present in th...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: Available online 9 December 2019Source: Progress in Lipid ResearchAuthor(s): M.I. McDermott, Y. Wang, M.J.O. Wakelam, V.A. BankaitisAbstractDespite being discovered over 60 years ago, the precise role of Phospholipase D (PLD) is still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of glycerophospholipids producing phosphatidic acid and the free headgroup. PLD family members are found in organisms ranging from viruses, and bacteria to plants, and mammals, and they display a range of substrate specificities, are regulated by a diverse range of molecules, and have been imp...
Source: Progress in Lipid Research - Category: Lipidology Source Type: research
Source: International Journal of Nanomedicine - Category: Nanotechnology Tags: Journal of Experimental Pharmacology Source Type: research
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Source: Meat Science - Category: Food Science Source Type: research
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Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusions: We demonstrated in the SOD1G93A model of ALS that increased levels of several cytokines were associated with a shorter lifespan. However, their role as prognostic biomarkers is unclear as their expression was very variable depending on both the disease stage and the subject. Nevertheless, cytokines may be potential therapeutic targets. Introduction Amyotrophic Lateral Sclerosis (ALS) is one of the most common rare diseases of unknown origin that leads to progressive motor neuron degeneration and muscle denervation (1). In particular, it has been described that either distal axonopathy or neuromuscular ju...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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Source: BMJ Open - Category: Journals (General) Authors: Tags: Open access, Geriatric medicine, Mental health, Neurology, Research methods Source Type: research
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