Serologic cross-reactivity between Sarcocystis neurona and Sarcocystis falcatula-like in experimentally infected Mongolian gerbils

Publication date: Available online 19 October 2019Source: Veterinary ParasitologyAuthor(s): Rogério F. de Jesus, Waléria Borges-Silva, Taynar L. Bezerra, Leane Q. Gondim, Rosângela S. Uzêda, Luís F.P. GondimAbstractSarcocystis neurona is the major cause of the equine protozoal myeloencephalitis (EPM) in the Americas and has opossums of the genus Didelphis as definitive hosts. Most isolates of Sarcocystis sp. shed by opossums in Brazil differ genetically from the known species of Sarcocystis. These Brazilian isolates behave similarly as Sarcocystis falcatula, which causes sarcocystosis in birds, and for this reason, have been classified as Sarcocystis falcatula-like. Genes coding for the immunodominant surface antigens SAG2, SAG3 and SAG4 of S. falcatula-like are similar to those from S. neurona. It is unknown the Sarcocystis species that causes EPM in Brazil, as S. neurona has never been genetically confirmed in Brazilian horses. All cases associated with EPM in Brazil were diagnosed by immunological tests, which are not specific for S. neurona infection. It is possible that S. falcatula-like may infect horses in Brazil. The aims of the current study were to test the susceptibility of gerbils (Meriones unguiculatus) to experimental infections with S. neurona and S. falcatula-like, and to investigate potential serologic cross-reactivity to these parasites by immunofluorescent antibody test (IFAT) and Western blot (WB). A total of 27 gerbils, di...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research

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Conclusion: Here we discuss the major implications of these findings for the association between microorganisms and cancer, and also between some immune pathologies, like autoimmune diseases, and cancer.
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research
Publication date: Available online 15 November 2019Source: Molecular and Biochemical ParasitologyAuthor(s): Marla I Hertz, Philip M Glaessner, Amy Rush, Philip J BudgeAbstractGalectins are among the most abundant excretory/secretory (ES) products of filarial worms, but their role in filarial biology is poorly understood. Galectin-2 (Lec-2), a major component of Brugia malayi extracellular vesicles, is released by filarial worms, and was recently identified in the serum of persons with loiasis. We therefore sought to clone and characterize Lec-2, and to develop reagents to examine its potential as a biomarker and its role i...
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
Publication date: November 2019Source: Saudi Journal of Biological Sciences, Volume 26, Issue 7Author(s): Mohamed A. Dkhil, Mona F. Khalil, Marwa S.M. Diab, Amira A. Bauomy, Simeon Santourlidis, Esam M. Al-Shaebi, Saleh Al-QuraishyAbstractNanomedicine is one of the most important methods used to treat human diseases including parasitic diseases. Schistosomiasis is a major parasitic disease that affects human health in tropical regions. Whilst Praziquantel is the main classic antischistosomal drug, new drugs are required due to the poor effect of the drug on the parasite juveniles and immature worms, and the emergence of dr...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
In conclusion, promising nonchemical (plant extracts) are innocuous to adult bees. So, we strongly believed that this effort was made to evaluate the status of medicinal plants researches globally.
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 15 November 2019Source: Chemico-Biological InteractionsAuthor(s): Paula Roberta da Silva, Jamerson Ferreira de Oliveira, Anekécia Lauro da Silva, Camila Marques Queiroz, Ana Paula Sampaio Feitosa, Denise Maria Figueiredo Araújo Duarte, Aline Caroline da Silva, Maria Carolina Accioly Brelaz de Castro, Valéria Rêgo Alves Pereira, Rosali Maria Ferreira da Silva, Luiz Carlos Alves, Fábio André Brayner dos Santos, Maria do Carmo Alves de LimaAbstractParasitic diseases still represent serious public health problems, since the high and steady emergence of...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to discuss the current knowledge of HIV and tissue parasite co-infection in the context of transmission enhancement, clinical characteristics, treatment, relapse, and clinical outcomes.Recent FindingsThe pathophysiology and clinical sequelae of tissue parasites in people living with HIV (PLWH) have been well described for only a handful of organisms, primarily protozoa such as malaria and leishmaniasis. Available published data indicate that the interactions between HIV and tissue parasites are highly variable depending on the infecting organism and the degree of host ...
Source: Current Infectious Disease Reports - Category: Infectious Diseases Source Type: research
ConclusionThese results indicate that A. farnesiana pods contain nematocidal compounds and might be promising natural anthelmintic agents against H. contortus. This leguminous plant could be used as a nutraceutical food source for the control of gastrointestinal nematodes in small ruminants.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: 14 November 2019Source: Cell, Volume 179, Issue 5Author(s): Rebecca R. Stanway, Ellen Bushell, Anush Chiappino-Pepe, Magali Roques, Theo Sanderson, Blandine Franke-Fayard, Reto Caldelari, Murielle Golomingi, Mary Nyonda, Vikash Pandey, Frank Schwach, Séverine Chevalley, Jai Ramesar, Tom Metcalf, Colin Herd, Paul-Christian Burda, Julian C. Rayner, Dominique Soldati-Favre, Chris J. Janse, Vassily HatzimanikatisSummaryPlasmodium gene functions in mosquito and liver stages remain poorly characterized due to limitations in the throughput of phenotyping at these stages. To fill this gap, we followed...
Source: Cell - Category: Cytology Source Type: research
Publication date: Available online 15 November 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Azita Navvabi, Ahmad Homaei, Shahram Khademvatan, Mohammad Hassan Khadem Ansari, Mousa KeshavarzAbstractEchinococcosis (hydatid cyst) is a zoonotic disease in sheep, cattle, pigs, rats, and humans that is caused by larvae of the tapeworm Echinococcus granulosus. Several studies have shown that invertebrates exhibit activity against various parasites, but no studies are available of effects of extracts of the sea urchin Echinometra mathaei on hydatid cysts. Here, E. mathaeis gonad extracts were investigated for t...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
CONCLUSIONS: These data contribute to a better understanding of the distribution of T. cruzi infection in the Northeastern region of Brazil. Preventive measures based on vector control should be implemented in the study ar ea in order to reduce the burden this neglected tropical disease.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
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