TPGS-mediated one-pot synthesis, XRD structural analysis, antimicrobial evaluation and molecular docking of novel heterocycles as potential inhibitors of p53-MDM2 protein

In this study, we discovered potent p53-MDM2 inhibition by 2-thiobenzyl-3-formyl quinoline, 2-thio-1,2-dihydroquinoline-3-formyl N-substituted thiosemi-carbazone and fluorine substituted new pyridine and pyran derivatives by structure-based design.Graphical abstract
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research