Combining radiotherapy with immunocheckpoint inhibitors or CAR-T in Renal Cell Carcinoma.

Combining radiotherapy with immunocheckpoint inhibitors or CAR-T in Renal Cell Carcinoma.
Curr Drug Targets. 2019 Oct 17;:
Authors: Santoni M, Heng DY, Aurilio G, Iozzelli A, Servi L, Fabiani A, Giannini M, Mazzucchelli R, Cimadamore A, Scarpelli M, Zaghloul MS, Battelli N, Montironi R
Abstract
Radiotherapy is living a second life in Renal Cell Carcinoma (RCC) patients, mainly due to the introduction of immunocheckpoint inhibitors, such as anti-Programmed-death (PD)-1, alone or in combination with anti-Cytotoxic T-Lymphocyte Antigen (CTLA)-4. Several trials are investigating the efficacy/safety of immunocheckpoint inhibitors in sequential or combined strategies with radiotherapy. Chimeric Antigen Receptor (CAR)-T cells therapy as a promising approach in cancer patients has opened the way to novel possibilities of integrating therapies. The identification of biomarkers of tumor response to these combinations represents a challenge in RCC, together with the research for the best partner for immunotherapy in metastatic patients. In this review we illustrated preclinical/clinical data on the integration of radiotherapy with immunocheckpoint inhibitors or CAR-T cells in RCC.
PMID: 31625471 [PubMed - as supplied by publisher]

Source: Current Drug Targets - October 16, 2019 Category: Drugs & Pharmacology Authors: Santoni M, Heng DY, Aurilio G, Iozzelli A, Servi L, Fabiani A, Giannini M, Mazzucchelli R, Cimadamore A, Scarpelli M, Zaghloul MS, Battelli N, Montironi R Tags: Curr Drug Targets Source Type: research