Fight Aging! Newsletter, October 21st 2019
In this study, AT1-AAs were detected in the sera of patients with peripheral arterial disease (PAD) and the positive rate was 44.44% vs. 17.46% in non-PAD volunteers. In addition, analysis showed that AT1-AAs level was positively correlated with PAD. To reveal the causal relationship between AT1-AAs and vascular aging, an AT1-AAs-positive rat model was established by active immunization. The carotid pulse wave velocity was higher, and the aortic endothelium-dependent vasodilatation was attenuated significantly in the immunized rats. Morphological staining showed thickening of the aortic wall. Histological examination showed that levels of the senescent markers were increased in the aortic tissue, mostly located at the endothelium. In addition, purified AT1-AAs-IgGs from both the immunized rats and PAD patients induced premature senescence in cultured human umbilical vein endothelial cells. These effects were significantly blocked by the AT1 receptor blocker. Taken together, our study demonstrates that AT1-AAs contribute to the progression of vascular aging and induce EC senescence through AT1 receptor. We Still Have a Long Way to Go in Telling the World that the Longevity Industry Exists https://www.fightaging.org/archives/2019/10/we-still-have-a-long-way-to-go-in-telling-the-world-that-the-longevity-industry-exists/ I have been slacking on conference reports these past few months, but largely because the conferences I was attending were not wholly dedicate...
Authors: Mendenhall E, Musau A, Bosire E, Mutiso V, Ndetei D, Rock M Abstract Type 2 diabetes mellitus is a condition that both results from and produces social and psychological suffering. As 'diabetes' increases among low income patients in poorer nations, new challenges arise that drive, co-occur, and result from the condition. In this article, we describe how social suffering produces diabetes by way of addressing the varied social, psychological, and biological factors that drive diabetes and are reflected in diabetes experiences among patients seeking care at a public hospital in Nairobi, Kenya. We recruited ...
Authors: Marín-Sánchez A Abstract The basic clinical characteristics of the first 100 fatal cases from COVID-19 in Colombia were analyzed based on reports from the National Institute of Health (INS) since the beginning of the pandemic. Since the INS records do not include clinical variables of comorbidity in the total number of cases reported as positive, but only in patients with fatal outcome, comorbidities, age and sex available in the daily INS reports were reviewed. Their frequency was identified and mortality risk behavior for the analyzed variables was established and compared with the behavior...
Authors: Sola A, Rodríguez S, Cardetti M, Dávila C Abstract Objective: To evaluate and report the clinical characteristics and outcomes of SARS-CoV-2 infection in pregnant women and newborns in Latin America. Methods: Descriptive study based on the prospective report of the units of the Ibero-American Society of Neonatology Network. Results: Of 86 pregnant women with COVID-19 confirmed by RT-PCR in seven countries (6 from Latin America, and Equatorial Guinea) 68% (59) were asymptomatic. Of 32% of symptomatic women, 89% (24) had mild symptoms and 3.5% (3) had severe respiratory symptoms. No wom...
Publication date: Available online 11 August 2020Source: Journal of Oral BiosciencesAuthor(s): Sho Akashi, Takashi Nishida, Tomomi Mizukawa, Kazumi Kawata, Masaharu Takigawa, Seiji Iida, Satoshi Kubota
Publication date: 1 December 2020Source: Carbohydrate Polymers, Volume 249Author(s): Shijie Dai, Shaozhong Liu, Chen Li, Zhifang Zhou, Zhimeng Wu
Publication date: 1 December 2020Source: Carbohydrate Polymers, Volume 249Author(s): Shuxian Hu, Rei Kuwabara, Martin Beukema, Michela Ferrari, Bart J. de Haan, Marthe T.C. Walvoort, Paul de Vos, Alexandra M. Smink
Publication date: Available online 11 August 2020Source: Carbohydrate PolymersAuthor(s): Sevil Vaghefi Moghaddam, Fatemeh Abedi, Effat Alizadeh, Behzad Baradaran, Nasim Annabi, Abolfazl Akbarzadeh, Soodabeh Davaran
Publication date: Available online 11 August 2020Source: Carbohydrate PolymersAuthor(s): Jingwen Luo, Tao Gong, Lixin Ma
Publication date: September 2020Source: Biomedical Signal Processing and Control, Volume 62Author(s): Gayathri S., Varun P. Gopi, P. Palanisamy
Publication date: September 2020Source: Biomedical Signal Processing and Control, Volume 62Author(s): Stephanos Leandrou, Demetris Lamnisos, Panicos A. Kyriacou, Stephanie Constanti, Constantinos S. Pattichis, for the Alzheimer's Disease Neuroimaging Initiative
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