Fight Aging! Newsletter, October 21st 2019

In this study, AT1-AAs were detected in the sera of patients with peripheral arterial disease (PAD) and the positive rate was 44.44% vs. 17.46% in non-PAD volunteers. In addition, analysis showed that AT1-AAs level was positively correlated with PAD. To reveal the causal relationship between AT1-AAs and vascular aging, an AT1-AAs-positive rat model was established by active immunization. The carotid pulse wave velocity was higher, and the aortic endothelium-dependent vasodilatation was attenuated significantly in the immunized rats. Morphological staining showed thickening of the aortic wall. Histological examination showed that levels of the senescent markers were increased in the aortic tissue, mostly located at the endothelium. In addition, purified AT1-AAs-IgGs from both the immunized rats and PAD patients induced premature senescence in cultured human umbilical vein endothelial cells. These effects were significantly blocked by the AT1 receptor blocker. Taken together, our study demonstrates that AT1-AAs contribute to the progression of vascular aging and induce EC senescence through AT1 receptor. We Still Have a Long Way to Go in Telling the World that the Longevity Industry Exists https://www.fightaging.org/archives/2019/10/we-still-have-a-long-way-to-go-in-telling-the-world-that-the-longevity-industry-exists/ I have been slacking on conference reports these past few months, but largely because the conferences I was attending were not wholly dedicate...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: Available online 13 November 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Pandiyan Nithya, Murugesan Balaji, Arumugam Mayakrishnan, Chinnalagu Dhilip Kumar, Selvaraj Rajesh, Azhagar Surya, Mahalingam SundrarajanAbstractThe noble metal such as Ag and Au doped CeO2 nanoparticles was successfully prepared by ionic liquid assisted hydrothermal method in the presence of Justicia adhatoda leaves extract and were used as an antibacterial and anticancer agent. The FT-IR and Raman spectrum exhibit the peaks at 460 and 464 cm−1 assigned to CeO stretching vibrations of NPs. The...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Abstract Long non-coding RNAs (lncRNAs) are implicated in various cellular and pathological processes. Two lncRNAs, myocardial infarction-associated transcript (MIAT) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), may be involved in the pathogenesis of coronary artery disease (CAD). Here, we aimed to determine the relative circulating levels of MIAT and MALAT1 in 110 stable CAD patients and 117 controls and to correlate their levels with the clinical and laboratory data. Peripheral blood expression levels were quantified by Real-Time qPCR. The median MIAT expression level in CAD patients was significa...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type globally and contributes significantly to burden of disease in South Asia. In Pakistan, HNSCC is among the most commonly diagnosed cancer in males and females. The increasing regional burden of HNSCC along with a unique set of risk factors merited a deeper investigation of the disease at the genomic level. Whole exome sequencing of HNSCC samples and matched normal genomic DNA analysis (n=7) was performed. Significant somatic single nucleotide variants (SNVs) were identified and pathway analysis performed to determine frequently affe...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
Publication date: December 2019Source: Journal of Transport &Health, Volume 15Author(s): Lake Sagaris, Daniel LanfrancoAbstractAn abundant literature has examined the usefulness of “safe routes to school” programs to increase active transport (mainly walking and cycling) and with it levels of physical activity, hence health. To date, these have been applied mainly in the Global North, where they are supported by national networks and government.Conditions in developing countries differ. While the obesity epidemic is rife, the sustainability trio of walk-bike-bus/Metro account for high percentages (66% or mo...
Source: Journal of Transport and Health - Category: Occupational Health Source Type: research
Publication date: November 2019Source: European Urology Supplements, Volume 18, Issue 10Author(s): Z.U. Rehman
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: November 2019Source: European Urology Supplements, Volume 18, Issue 10Author(s): C. Van Der Fels, S. Palthe, M.C. Van Den Heuvel, I.J. De Jong
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: November 2019Source: European Urology Supplements, Volume 18, Issue 10Author(s): R. Bientinesi, V. Di Paola, R. Manfredi, P. Bassi
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: November 2019Source: European Urology Supplements, Volume 18, Issue 10Author(s): X. Yu, G. Fan
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: November 2019Source: European Urology Supplements, Volume 18, Issue 10Author(s): L. Lopez, J. Rivière, G. Pierquet, J. Piéchaud-Kressmann, J-L. Hoepffner, J-B. Roche, R. Gaston, J. Rouffilange, T. Piéchaud
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: November 2019Source: European Urology Supplements, Volume 18, Issue 10Author(s): R. Rodrigues Fonseca, R. Lains Mota, I. Peyroteo, A. Bilé Silva, J.C. Santos, F. Alpoim Lopes, A. Covita, A. Canhoto, P. Monteiro, R. Nogueira, L. Abranches Monteiro
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
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