Fight Aging! Newsletter, October 21st 2019

In this study, AT1-AAs were detected in the sera of patients with peripheral arterial disease (PAD) and the positive rate was 44.44% vs. 17.46% in non-PAD volunteers. In addition, analysis showed that AT1-AAs level was positively correlated with PAD. To reveal the causal relationship between AT1-AAs and vascular aging, an AT1-AAs-positive rat model was established by active immunization. The carotid pulse wave velocity was higher, and the aortic endothelium-dependent vasodilatation was attenuated significantly in the immunized rats. Morphological staining showed thickening of the aortic wall. Histological examination showed that levels of the senescent markers were increased in the aortic tissue, mostly located at the endothelium. In addition, purified AT1-AAs-IgGs from both the immunized rats and PAD patients induced premature senescence in cultured human umbilical vein endothelial cells. These effects were significantly blocked by the AT1 receptor blocker. Taken together, our study demonstrates that AT1-AAs contribute to the progression of vascular aging and induce EC senescence through AT1 receptor. We Still Have a Long Way to Go in Telling the World that the Longevity Industry Exists https://www.fightaging.org/archives/2019/10/we-still-have-a-long-way-to-go-in-telling-the-world-that-the-longevity-industry-exists/ I have been slacking on conference reports these past few months, but largely because the conferences I was attending were not wholly dedicat...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs