Rapid progression of a low-grade follicular lymphoma with foci of high proliferation index and BCL6 rearrangement into a diffuse large B-cell lymphoma: A case report and review of the literature

We present a case study of a 74-year-old male who presented with right side flank pain and inguinal lymphadenopathy. The patient was diagnosed with low-grade follicular B-cell lymphoma with a low proliferative index (LGFL-LPI) and focal high proliferation index. Approximately 6 months later, the patient was diagnosed with LGFL-HPI with evidence of transformation into DLBCL of activated B-cell immunophenotype within the same lymph node. Separate fluorescence in situ hybridization (FISH) studies performed on the initial biopsy, the low grade component of the subsequent sample, and the transformed component of the subsequent sample were identical, revealing BCL2 and BCL6 gene rearrangements without MYC rearrangement in all components. As BCL6 rearrangement in a FL has been reported as a harbinger of transformation of FL into DLBCL, we believe that the short timeframe of transformation in our case may be attributed to the presence of BCL6 rearrangement in combination with the high proliferation index. This phenomenon of rapid transformation of FL into DLBCL with presence of a combination of BCL6 gene rearrangement and high proliferation index in both lymphomas has not been previously reported to our knowledge. We suggest that the presence of a combination of BCL6 rearrangement and high proliferation index could be an important prognostic factor, and its role in rapid progression of FL should be further investigated in larger studies.
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research

Related Links:

CONCLUSION: The etiology of chronic groin pain post hernia repair is related in part to nerve injury. This is supported by the high frequency of sensory symptoms and numbness in these patients. However other factors including the role of tissue injury and inflammatory postoperative changes need to be considered. KEY WORDS: Chronic postoperative pain, Inguinal hernia repair, Open surgery, Laparoscopic surgery. PMID: 31719216 [PubMed - as supplied by publisher]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
In this study, a strategy for the simultaneous quantification of 28 nucleobases, nucleosides, and nucleotides using hydrophilic interaction chromatography coupled with tandem mass spectrometry (HILIC-MS/MS) with positive/negative ion switching was developed. This method showed good linearity, precision, repeatability, and recovery. Furthermore, it was successfully applied to monitor the postmortem nucleotide degradation of turbot mince during chill (4 °C) and partial freezing (−3 °C) storage for 168 h. It was noted that the patterns of the changes in nucleotide metabolites differed considerably depending on t...
Source: Food Chemistry - Category: Food Science Source Type: research
The objective of this paper is to synthesise current knowledge on ALK rearrangement and its impact on the management of advanced NSCLC. Several inhibitors of the tyrosine kinase of ALK (crizotinib, ceritinib, alectinib) have been approved as first line therapies in patients with advanced ALK positive NSCLC, which are associated with a better median progression-free survival than conventional chemotherapy. Unfortunately, the emergence of drug resistance leads to tumor progression. In patients with oligoprogressive disease if local ablative therapy can be effected, continuing with the same ALK tyrosine kinase inhibitor is on...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Abstract The Editor-in-Chief has retracted this article [1] because an investigation by Keio University has concluded that there are inaccuracies in the data reported. PMID: 31730223 [PubMed - in process]
Source: Aging Clinical and Experimental Research - Category: Geriatrics Authors: Tags: Aging Clin Exp Res Source Type: research
Publication date: Available online 16 November 2019Source: Artificial Intelligence in MedicineAuthor(s): Anam Mustaqeem, Syed Muhammad Anwar, Muhammad MajidAbstractIn the last few years, hospitals have been collecting a large amount of health related digital data for patients. This includes clinical test reports, treatment updates and disease diagnosis. The information extracted from this data is used for clinical decisions and treatment recommendations. Among health recommender systems, collaborative filtering technique has gained a significant success. However, traditional collaborative filtering algorithms are facing ch...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Publication date: Available online 15 November 2019Source: Fuß &SprunggelenkAuthor(s): Hubert Hörterer, Sebastian Felix Baumbach, Mareen Braunstein, Ulrike Szeimies, Wolfgang Böcker, Markus Walther, Hans PolzerZusammenfassungSchmerzen am Ansatz der Achillessehne stellen mit einer Lebenszeitinzidenz von 6% ein häufiges Krankheitsbild dar. Mittels klinischer Untersuchung, Röntgen und MRT können die Pathologien entsprechend ihrer Lokalisation in drei verschiedene Kompartimente (retro-, intra-, prä-achillär) eingeteilt werden. Führt die konservative Therapie nicht zu einer ausr...
Source: Fuss and Sprunggelenk - Category: Podiatry Source Type: research
Authors: Herrera AF PMID: 31730577 [PubMed - in process]
Source: Clinical Advances in Hematology and Oncology - Category: Cancer & Oncology Tags: Clin Adv Hematol Oncol Source Type: research
Authors: PMID: 31730576 [PubMed - in process]
Source: Clinical Advances in Hematology and Oncology - Category: Cancer & Oncology Tags: Clin Adv Hematol Oncol Source Type: research
ConclusionsIn skeletal muscle, GSK-3β inactivation causes dephosphorylation and nuclear translocation of TFEB resulting in TFEB-dependent induction of Pgc-1α expression.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Authors: Ivan I, Climent F, Mercadal S PMID: 31722786 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
More News: Fish | Genetics | Lymphoma | Non-Hodgkin's Lymphoma | Pain | Pathology | Study | Translocation