T cell addiction: can pathogenic T cells be controlled using dopamine receptors?

T cell addiction: can pathogenic T cells be controlled using dopamine receptors? Immunology. 2019 Nov;158(3):151-152 Authors: Bain KA, Milling S Abstract Crosstalk between the immune system and the nervous system, via neurotransmitters such as dopamine, is increasingly of interest as we begin to learn how lymphocytes in peripheral tissues can both produce and respond to these molecules. This crosstalk can modulate immune responses by influencing the local tissue environment and can, for instance, influence the activation status and migration of T cells. Immune cells also use neurotransmitters to communicate with each other. Understanding how neurotransmitters influence the immune system may provide novel approaches for targeting diseases associated with tissue-specific inflammation, such as psoriasis. PMID: 31625164 [PubMed - in process]
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research

Related Links:

How can conventional dietary advice gotten it so wrong? Rather than eating plenty of “healthy whole grains,” people on the Wheat Belly lifestyle eat absolutely no grains and enjoy spectacular weight loss and reversal of hundreds of health conditions as a result. Unfortunately, many people view this as a “gluten-free” lifestyle which is incorrect. Here are 10 reasons why no bagels, pretzels, or sandwiches made from wheat flour should ever cross human lips. Gliadin-derived opioid peptides (from partial digestion to 4- and 5-amino acid long fragments) increase appetite substantially–as do related...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle Gliadin gluten Inflammation Weight Loss Source Type: blogs
Abstract Naltrexone is a competitive opioid receptor antagonist approved as supportive treatment in alcohol dependence and opioid addiction. In a dose 50-100 mg daily, naltrexone is used off-label in dermatology for the treatment of trichotillomania and different types of pruritus. At a dose as low as 1-5 mg of drug per day, naltrexone demonstrates immunomodulatory action i.e. modulates Toll-like receptors signaling, decreases release of proinflammatory cytokines (tumor necrosis factor, interleukin-6, interleukin-12), inhibits T lymphocyte proliferation, down-regulates the expression of chemokine receptors and adh...
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research
This study examined the risks of a range of adverse events in a large cohort of patients prescribed long‐term opioids using the UK Clinical Practice Research Datalink.MethodsPatients with musculoskeletal conditions starting a new long ‐term opioid episode (defined as ≥3 opioid prescriptions within 90 days) between 2002‐2012 were included. Primary outcomes: major trauma and intentional overdose (any). Secondary outcomes: addiction (any), falls, accidental poisoning, attempted suicide/self‐harm, gastrointestinal pathology a nd bleeding, and iron deficiency anaemia. ‘Control’ outcomes (unrelated to opio...
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
You're reading Hypnosis – what’s fact and what’s fiction?, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Hypnosis is a technique that is both widely used and controversial. Many see it as a form of stage entertainment. True hypnosis, however, is very different and has valuable medical and therapeutic benefits, providing effective treatment to a variety of ailments - from anxiety and depression to chronic pain. To help you gain a deeper understanding of hypnosis, let’s look at how it works and unp...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured self improvement health hypnosis pickthebrain Source Type: blogs
There are plenty of reasons to never allow a bagel, sandwich, or pretzels to cross your lips again. But here are the top 10 most powerful and compelling reasons to tell the USDA and other providers of dietary advice to bug off with their “healthy whole grains” nonsense. Gliadin-derived opioid peptides (from partial digestion to 4- and 5-amino acid long fragments) increase appetite substantially–as do related proteins from rye, barley, and corn. This is a big part of the reason why grains make you gain weight. Gliadin-derived opioid peptides are mind active drugs that trigger behavioral outbursts in kids ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates autoimmune blood sugar Gliadin gluten gluten-free grain-free grains Inflammation joint pain low-carb wheat belly Source Type: blogs
You're reading 10 Ways Chronic Stress Is Killing Your Quality Of Life, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Stress is something which is almost unavoidable in modern life. While the right amount of stress motivates individual performance, it is necessary if you could distinguish whether your stress is good or chronic. Chronic stress derives from repeated interaction of the body to intense and stressful situations, contributing to the release of stress hormone. The stress is troublesome when it comes to chronic,...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: depression featured self improvement anxiety bad habits chronic stress Source Type: blogs
It will take more than medication alone to win the battle against opioid addiction, and now U.S. clinicians finally have a device-based therapy to help reduce the symptoms of opioid withdrawal. FDA granted a new indication to Innovative Health Solutions for its NSS-2 Bridge nerve stimulator. The new indication was reviewed under FDA's de novo pathway. “There are three approved drugs for helping treat opioid addiction. While we continue to pursue better medicines for the treatment of opioid use disorder, we also need to look to devices that can assist in this therapy,” said FDA Commissioner Scott Gottlieb, MD. G...
Source: MDDI - Category: Medical Devices Authors: Tags: Regulatory and Compliance Source Type: news
The FDA has given a regulatory green light to the first device that reduces opioid withdrawal symptoms. The NSS-2 Bridge from Innovative Health Solutions, a Versailles, Indiana firm, is stuck to the skin behind the ear and relies on four electrodes t...
Source: Medgadget - Category: Medical Devices Authors: Tags: Medicine Neurology Pain Management Psychiatry Source Type: blogs
Abstract BackgroundDistal interphalangeal (DIP) arthritis is a frequent form of psoriatic arthritis being often linked to nail psoriasis. Modern society is characterized by over‐use of smartphones. Indeed, literature has recently focalized on research into smartphone addiction and health related problems. ObjectivesSince smartphone addiction is able to determine over‐use and repeated movements of DIP joints and nails, the aim of this study was to evaluate the impact of smartphone use on hand joints of young psoriatic patients. MethodsAn observational study involving 4 different groups such as non smartphone addicted (S...
Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Original Article Source Type: research
ConclusionsAlcohol‐dependent men and women have significantly higher risks of a comprehensive spectrum of somatic diseases, both as disease events and as causes of death, relative to individuals from the general population.
Source: Addiction - Category: Addiction Authors: Tags: Research Report Source Type: research
More News: Addiction | Allergy & Immunology | Brain | Environmental Health | Learning | Neurology | Psoriasis | Universities & Medical Training