Myocarditis: Uncommon but severe toxicity of immune checkpoint inhibitors.

[Myocarditis: Uncommon but severe toxicity of immune checkpoint inhibitors]. Bull Cancer. 2019 Oct 15;: Authors: Courand PY, Bouali A, Harbaoui B, Cautela J, Thuny F, Lantelme P Abstract Traditional cancer therapies, such as treatment with anthracyclines and chest radiation, are known to induce cardiovascular complications. Currently, the increase of cancer therapies will involve new mechanisms such as cancer immunotherapies, also called immune checkpoint inhibitors (PD-1, PD-L1 and CTLA-4 inhibitors). These treatments have shown long-term remissions in subgroup of cancers, including melanomas, non-small-cell lung cancer, urothelial carcinoma, renal cell carcinoma, squamous cell carcinoma of the head and neck and colorectal cancer. Although these treatments will change the natural course of these cancers, they may sometimes induce cardiovascular complications, which has been reported as about 1 % in the literature. Currently, the physicians must keep in mind one uncommon but severe cardiac complication: auto-immune myocarditis. The clinical presentation may include various symptoms like chest pain, heart failure or rhythm disorders. In this situation, a baseline cardiologic check-up before starting cancer immunotherapy may be very helpful. Cardiac biomarkers (troponin and brain natriuretic peptide) and 12-lead resting electrocardiogram must be promptly performed when myocarditis is suspected. A cardiologist's opinion must be requested in emergency t...
Source: Bulletin du Cancer - Category: Cancer & Oncology Authors: Tags: Bull Cancer Source Type: research

Related Links:

CONCLUSIONS: Considering the age group in which rectal prolapse is most commonly seen, and the change in bowel habits, chronic constipation and irritation chronic seen in rectal prolapse may be responsible for the development of rectum cancer, therefore endoscopic screening should not be overlooked in rectal prolapse cases. KEY WORDS: Anorectal emergencies, Colon cancer, Rectal prolapse. PMID: 31723051 [PubMed - in process]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
CONCLUSION: The etiology of chronic groin pain post hernia repair is related in part to nerve injury. This is supported by the high frequency of sensory symptoms and numbness in these patients. However other factors including the role of tissue injury and inflammatory postoperative changes need to be considered. KEY WORDS: Chronic postoperative pain, Inguinal hernia repair, Open surgery, Laparoscopic surgery. PMID: 31719216 [PubMed - as supplied by publisher]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Publication date: Available online 15 November 2019Source: Trends in Food Science &TechnologyAuthor(s): Ryoiti KiyamaAbstractBackgroundGreen tea is produced from the tea plant Camellia sinensis without fermentation, and contains characteristic constituents, which are associated with health-promoting effects such as physiological, immunological, neurological and psychological effects, and protective effects against diseases, such as cancer, cardiovascular diseases and diabetes. Catechins, such as catechin, epicatechin, epigallocatechin, epicatechin-3-O-gallate and epigallocatechin-3-O-gallate, and other green tea consti...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
CONCLUSIONS: Both STX3451 and STX2895 provide new approaches for inducing cell death and lowering tumour burden in NF2 as well as in NF1, which both have limited treatment options. PMID: 31730023 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
CONCLUSIONS: The matrices and the questionnaire have a great diagnostic performance which seems interesting for a use as a screening tool for occupational exposures. These results have yet to be confirmed by large-scale studies. PMID: 31727556 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
The objective of this paper is to synthesise current knowledge on ALK rearrangement and its impact on the management of advanced NSCLC. Several inhibitors of the tyrosine kinase of ALK (crizotinib, ceritinib, alectinib) have been approved as first line therapies in patients with advanced ALK positive NSCLC, which are associated with a better median progression-free survival than conventional chemotherapy. Unfortunately, the emergence of drug resistance leads to tumor progression. In patients with oligoprogressive disease if local ablative therapy can be effected, continuing with the same ALK tyrosine kinase inhibitor is on...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Abstract The Editor-in-Chief has retracted this article [1] because an investigation by Keio University has concluded that there are inaccuracies in the data reported. PMID: 31730223 [PubMed - in process]
Source: Aging Clinical and Experimental Research - Category: Geriatrics Authors: Tags: Aging Clin Exp Res Source Type: research
Publication date: Available online 16 November 2019Source: Artificial Intelligence in MedicineAuthor(s): Anam Mustaqeem, Syed Muhammad Anwar, Muhammad MajidAbstractIn the last few years, hospitals have been collecting a large amount of health related digital data for patients. This includes clinical test reports, treatment updates and disease diagnosis. The information extracted from this data is used for clinical decisions and treatment recommendations. Among health recommender systems, collaborative filtering technique has gained a significant success. However, traditional collaborative filtering algorithms are facing ch...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Authors: Singh A, Karnik R, Shah AN, Chutani S, Kantharia BK Abstract Aims: Response to cardiac resynchronisation therapy (CRT) in patients with heart failure depends on the degree of correction of electromechanical dyssynchrony between the left and right ventricles (LV, RV). It is not known whether chronic programming of interventricular (VV) intervals based on characterisation of myocardial strain at different pacing intervals performed acutely would have better long-term clinical outcomes. We hence aimed to evaluate this relationship between speckle tracking strain patterns and rates at different VV intervals an...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Publication date: Available online 15 November 2019Source: Fuß &SprunggelenkAuthor(s): Hubert Hörterer, Sebastian Felix Baumbach, Mareen Braunstein, Ulrike Szeimies, Wolfgang Böcker, Markus Walther, Hans PolzerZusammenfassungSchmerzen am Ansatz der Achillessehne stellen mit einer Lebenszeitinzidenz von 6% ein häufiges Krankheitsbild dar. Mittels klinischer Untersuchung, Röntgen und MRT können die Pathologien entsprechend ihrer Lokalisation in drei verschiedene Kompartimente (retro-, intra-, prä-achillär) eingeteilt werden. Führt die konservative Therapie nicht zu einer ausr...
Source: Fuss and Sprunggelenk - Category: Podiatry Source Type: research
More News: Brain | Brain Cancers | Cancer | Cancer & Oncology | Cancer Therapy | Carcinoma | Cardiology | Cardiovascular | Colorectal Cancer | Electrocardiogram | Emergency Medicine | Head and Neck Cancer | Heart | Heart Failure | Immunotherapy | Intensive Care | Kidney Cancer | Lung Cancer | Myocarditis | Neurology | Non-Small Cell Lung Cancer | Pain | Renal Cell Carcinoma | Skin Cancer | Squamous Cell Carcinoma | Toxicology