Brain A β load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD.

DISCUSSION: Our results suggest a sexual dimorphism in BACE1-related upstream mechanisms of brain Aβ production and deposition. We argue that plasma BACE1 should be considered in further biomarker validation and qualification studies as well as in BACE1 clinical trials. PMID: 31627825 [PubMed - in process]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsThis study demonstrates biomarker-based MCI prognosis and supports its role in clinical decision-making in daily practice.ResumenObjetivoEl objetivo de este estudio fue investigar el rol y pronóstico de los biomarcadores de enfermedad de Alzheimer en pacientes con diagnóstico clínico de deterioro cognitivo leve (DCL) en una clínica de memoria de Latinoamérica.MétodoOchenta y nueve pacientes con DCL, 43 con demencia tipo Alzheimer y 18 controles normales apareados por edad, sexo y escolaridad fueron estudiados con un extenso protocolo demográfico, neurológic...
Source: Neurologia - Category: Neurology Source Type: research
ConclusionsSimilar to AD, the interpretation of [18F]THK5351 uptake in PSP is likely confounded by off-target binding to MAO-B binding sites. [18F]THK5351 is not sufficient in quantifying tau aggregates in PSP using the proposed rasagiline dosing regimen.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
CONCLUSION: These findings suggested that occipitoparietal cortex, posterior cingulate cortex and precuneus, which were particularly affected by increased tau accumulation in VS-AD patients, may associate with visuospatial dysfunction of AD. PMID: 31724513 [PubMed - as supplied by publisher]
Source: Current Alzheimer Research - Category: Neurology Authors: Tags: Curr Alzheimer Res Source Type: research
Amyvid (florbetapir f18, [18F]AV ‐45, [18F]5) was the first FDA approved positron emission tomography (PET) imaging agent targeting β‐amyloid (Aβ) plaques for assisting the diagnosis of Alzheimer's disease. This work aimed to improve the [18F]AV ‐45 ([18F]5) preparation by using solid ‐phase extraction (SPE) purification. [18F]AV ‐45 ([18F]5) was synthesized by direct nucleophilic radiofluorination ofO‐tosylated precursor (1 mg) at 120 °C in anhydrous dimethyl sulfoxide (DMSO), followed by acid hydrolysis of theN‐Boc protecting group. Purification was accomplished by loading the crude reaction m...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
Publication date: Available online 4 November 2019Source: NeuroImage: ClinicalAuthor(s): Iman Beheshti, Scott Nugent, Olivier Potvin, Simon DuchesneAbstractThe level of prediction error in the brain age estimation frameworks is associated with the authenticity of statistical inference on the basis of regression models. In this paper, we present an efficacious and plain bias-adjustment scheme using chronological age as a covariate through the training set for downgrading the prediction bias in a Brain-age estimation framework. We applied proposed bias-adjustment scheme coupled by a machine learning-based brain age framework...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
PET/MRI scans show middle-aged adults with high vascular risk factors have...Read more on AuntMinnie.comRelated Reading: PET, MRI show physical activity aids brain health SNMMI: Cerebrovascular risk tied to Alzheimer's disease MRI ties high blood pressure to dementia risk PET links amyloid, vascular factors to cognitive decline PET links midlife vascular risk factors to more amyloid
Source: Headlines - Category: Radiology Source Type: news
Despite the importance of Aβ aggregation in Alzheimer’s disease etiology, our understanding of the sequence determinants of aggregation is sparse and largely derived from in vitro studies. For example, in vitro proline and alanine scanning mutagenesis of Aβ40 proposed core regions important for aggregation. However, we lack even this limited mutagenesis data for the more disease-relevant Aβ42. Thus, to better understand the molecular determinants of Aβ42 aggregation in a cell-based system, we combined a yeast DHFR aggregation assay with deep mutational scanning. We measured the effect of 791 of th...
Source: G3: Genes Genomes Genetics - Category: Genetics & Stem Cells Authors: Tags: Investigations Source Type: research
Publication date: Available online 1 November 2019Source: NeuroscienceAuthor(s): Hala El Khoury, John Mitrofanis, Luke A HendersonAbstractWe explore whether near infrared light can change patterns of resting (task-negative) and/or evoked (task-positive; eg finger-tapping) brain activity in normal, young human subjects using fMRI (functional magnetic resonance imaging). To this end, we used a vielight transcranial device (810nm) and compared the scans in subjects after active- and sham-light sessions. Our fMRI results showed that, while light had no effect on cerebral blood flow and global resting state brain activity (task...
Source: Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 1 November 2019Source: NeuroImageAuthor(s): Meral A. Tubi, Franklin W. Feingold, Deydeep Kothapalli, Evan T. Hare, Kevin S. King, Paul M. Thompson, Meredith N. Braskie, Alzheimer's Disease Neuroimaging InitiativeAbstractWhite matter hyperintensities (WMH) are brain white matter lesions that are hyperintense on fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) scans. Larger WMH volumes have been associated with Alzheimer's Disease (AD) and with cognitive decline. However, the relationship between WMH volumes and cross-sectional cognitive measures has been inconsi...
Source: NeuroImage - Category: Neuroscience Source Type: research
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