Association of miRNA-27a and leptin polymorphisms with recurrent pregnancy loss in Egyptian women

Publication date: Available online 18 October 2019Source: Meta GeneAuthor(s): Mai Shaker, Taghreed Shalabi, Khaled R. Gaber, Khalda AmrAbstractBackgroundLeptin is an important hormone during implantation processes and plays a pivotal role in regulating the development of placenta and endo-metrial receptivity. miRNAs are associated with endometrial diseases, preeclampsia, neural tube defects and infertility, providing their potential role in the function of normal reproductive system. The aim of this study was to investigate the role of miRNA-27a and leptin polymorphisms in the development of idiopathic recurrent pregnancy loss (RPL) among Egyptian women.MethodsThis is a case-control study involving 99 women with at least two consecutive recurrent pregnancy losses and 100 females as a control group. The rs7799039 G/A variant in leptin gene (LEP) and miR-27a rs895819 were genotyped by polymerase chain reaction-restriction fragment length polymorphism assay. Odds ratios and 95% confidence intervals were estimated using multivariate analyses. The relationships between the genotypes of each of the two polymorphism genotypes and incidence of RPL as well as other parameters (body mass index, consanguinity, no of abortion and timing of abortion of the RPL patients) were analyzed using multiple linear regression analyses.ResultsStatistical analysis showed that rs7799039 G/A was associated with an increased risk of RPL GA + AA (0.006;0.379 (0.190–0.758) (GG vs. GA: OR ≤0...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research

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We report a case of a 36-year-old woman with type 2 diabetes mellitus and a one-year of primary infertility. Following oral ovulation induction cycles and IUI, diagnosis of heterotopic cervical pregnancy was made by ultrasonography at 7.4 weeks of gestation. Laser ablation of the cervical pregnancy was performed achieving adequate homeostasis at the implantation site and preserving the intrauterine pregnancy. A healthy infant was delivered at 36 0/7 wks by cesarean-section.Laser ablation is a minimally invasive procedure that appears to lead to successful outcomes in treatment of heterotopic cervical pregnancy.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: Available online 14 November 2019Source: World Journal of Acupuncture - MoxibustionAuthor(s): Chen-si Zheng, Yi-gong FangAbstractThis paper reports one case of successful pregnancy in the assistance of acupuncture therapy for regulating menstruation and promoting pregnancy and the periodic intervention with Chinese herbal medicine in a 41-year-old patient with infertility. The patient suffered from 11 failures in the assisted reproductive technique during 3 years. This case suggests that the combined treatment with acupuncture for regulating menstruation and promoting pregnancy and the periodic interventi...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
[New Era] The First Lady, Monica Geingos, has said infertility in Namibia should be treated like any other health issue: with professionalism, empathy, respect and stigma. "It is not always the women's fault; men too can struggle with infertility. Couples would not know if they are not both exposed to medical examinations and tests," explained Geingos.
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
We report a case of a 36-year-old woman with type 2 diabetes mellitus and a one-year of primary infertility. Following oral ovulation induction cycles and IUI, diagnosis of heterotopic cervical pregnancy was made by ultrasonography at 7.4 weeks of gestation. Laser ablation of the cervical pregnancy was performed achieving adequate homeostasis at the implantation site and preserving the intrauterine pregnancy.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Case Repot Source Type: research
ConclusionObesity is closely associated with primary infertility and PCOD. Menstrual abnormalities associated with PCOD significantly improve after bariatric surgery with significant improvement in fertility along with maternal outcomes.
Source: Obesity Surgery - Category: Surgery Source Type: research
UNFPA-supported midwives ensured that this young woman gave birth safely in Bor Hospital, South Sudan. © UNFPA South SudanBy Julitta OnabanjoJOHANNESBURG, South Africa, Nov 12 2019 (IPS) This is a special year for all rights-based health advocates, as we celebrate 25 years of the International Conference on Population and Development (ICPD). At the ICPD in Cairo in 1994, for the first time world leaders from 179 member states committed to the principles that underpin today’s Sustainable Development Goals: non-discrimination and universality; the centrality of health, including sexual and reproductive health and...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa Gender Headlines Health Population Poverty & SDGs TerraViva United Nations ICPD25 International Conference on Population and Development (ICPD25) Source Type: news
Abstract The Folic Acid and Zinc Supplementation Trial (FAZST) was a multi-center, double-blind, block-randomized, placebo-controlled trial to determine whether folic acid and zinc supplementation in men improves semen quality and increases live birth rate among couples seeking infertility treatment (2013-2017). Eligible men were ages 18 years or older with their female partners ages 18-45 seeking infertility treatment. Men were randomized (1:1) to 5 mg folic acid and 30 mg elemental zinc daily or matching placebo for six months. Randomization was stratified by site and intended infertility treatment (in vitro fer...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
In this study, we evaluated a novel multiplex real-time PCR melting curve assay method for the simultaneous detection of 9 STD pathogens, including Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis, Mycoplasma hominis, Ureaplasma urealyticum, Ureaplasma parvum, and herpes simplex virus.Methods: The analytical performance of the method, including its limit of detection (LOD), specificity, repeatability, and effect on different DNA extraction kits were evaluated. Additionally, we obtained 1,328 clinical specimens from 3 hospitals to detect the 9 STD pathogens using multiplex real-time...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
The human endometrium is essential in providing the site for implantation and maintaining the growth and survival of the conceptus. An unreceptive endometrium and disrupted maternal−conceptus interactions can cause infertility due to pregnancy loss or later pregnancy complications. Despite this, the role of uterine glands in first trimester human pregnancy...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
Conclusions: Maternal advanced endometriosis might increase the risk of congenital malformations for infants born after IVF-ET. The organ system most frequently affected by congenital malformations was the cardiovascular system, followed by the musculoskeletal system.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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