Direct-acting antiviral drugs improve the female sexual burden associated with chronic HCV infection.

Direct-acting antiviral drugs improve the female sexual burden associated with chronic HCV infection. Expert Rev Anti Infect Ther. 2019 Oct 18;: Authors: Elshimi E, Sakr N, Morad W, Mohamad NE, Waked I Abstract Background: The impact of patient cure by direct-acting antiviral agents (DAAs) on female sexual dysfunction (FSD) associated with HCV hasn't been studied. Aim: To study the impact of DAAs on associated FSD in patients with chronic HCV infection. Methods: In patients with chronic HCV infection who were eligible for DAAs, the self-administered female-sexual-function index (FSFI) questionnaire was completed by 300 sexually active females' patients before treatment and compared to equal number of age and socioeconomically matched controls. FSFI questionnaire results after treatment were compared to patients' baseline results. Results: The mean total score for the patients was significantly lower than that for controls (16.77 ± 1.36 versus 17.52 ± 0.99, P
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research

Related Links:

AbstractPurpose of reviewIn this review article, we evaluate sex differences in the natural history of NAFLD and highlight distinct risk profiles of women with NAFLD, as well as unique treatment considerations and research gaps.Summary of FindingsReproductive factors, such as menopausal status, should be considered when evaluating NAFLD risk in women, as well as additional reproductive risk factors such as age at menarche, presence of polycystic ovary syndrome, and gestational diabetes. Women do appear to have lower risk for hepatocellular carcinoma from NASH, as well as lower mortality from NASH cirrhosis than men, althou...
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research
We present a case of female patient who was referred to the consultation because she was about to start chemotherapy with an anti-CD20 agent and had a positive anti-HBc and anti-HBs. During routine workup an occult hepatitis B virus infection was diagnosed. Upon further study mutations in the PreCore and Basal Core Promoter regions were identified, as well as, a double genotype D/C. Therapy with tenofovir was initiated before the patient was started on chemotherapy. This case highlights the importance of comprehensive studying of patients who present with apparently resolved chronic hepatitis B virus infection, especially ...
Source: IDCases - Category: Infectious Diseases Source Type: research
We examined US sensitivity for diagnosis of HCC in obese patients. Methods: Liver transplant patients data with HCC in explant was used (January 2012-December 2017). All patients underwent liver US within 3 months of diagnosis of HCC. Number/size of HCC lesions were extracted from radiologic and pathologic reports. Obesity was defined as BMI ≥30 kg/m2. Results: One hundred sixteen patients were included. 80% were male, with mean BMI of 31 kg/m2. The most common underlying liver disease was hepatitis C virus (62%). At the time of diagnosis, median number of HCC lesions was 2 (interquartile range [IQR], 1-3), and ...
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
Publication date: November 2019Source: European Urology Supplements, Volume 18, Issue 11Author(s): I. Tsimafeyeu, S. Protsenko, R. Gafanov, A. Semenova, A. Oganesyan, N. Nurgaliyev, S. Krasny, A. Bondarenko, S. Safina, K. Zakurdaeva
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
This study aims to analyze the prevalence and to concentrate on the key risk factors that are responsible for hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infection in patients on HD visiting two dialysis centers in the city of Quetta in southwestern Pakistan. The overall incidence of HBV was found to be 16.1%, the overall incidence of HCV was found to be 43.2%, and two patients (1.6%) were found to be positive for both HBV and HCV. HIV was not found among patients seen at both hospitals during the study period. The main risk factors for development of a viral infection were the ...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
ConclusionsAcute VZV infection may present as fulminant hepatitis. The presentation may initially be challenging for the diagnosis and should be considered if the patient has been in contact with a sick case. Low dose corticosteroid could carry a risk for fatal VZV fulminant hepatitis and should be used very cautiously especially with VZV patients’ contacts. Further causative relationships remain to be established.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Chronic hepatitis C virus (HCV) infection is a systematic disease that affects several aspects of patients’ well-being, including physical, mental, social, and sexual quality of life. In recent years, there has been a growing body of literature focusing on HCV patients’ sexual health, providing evidence of clinically significant and enduring disturbances that disrupt everyday living, but commonly evade clinicians’ attention. Relevant studies are characterized by considerable methodological heterogeneity and their findings should be interpreted using a systematic and integrative approach. In this context, ...
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Review Articles Source Type: research
In this month’s article, I explore issues relating to the health of women in emerging markets. I will recommend that pharma companies wishing to maximize the opportunity in women’s health need to start from an understanding of how women are viewed by society in these markets and challenge awareness, attitudes and access barriers that can lead to their health outcomes being sub-optimal. As a starting point, it is necessary to establish a working definition of women’s health.  This isn’t as straightforward as it might seem, as women’s health can be considered at multiple levels.  The c...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
ConclusionsIn our thalassemic patients iron overload and chronic liver disease appear to play a role in the development of AHH.  Treatment of AHH in TM patients is an important and vibrant field for improving their health and QOL. Early identification and management of AHH is very crucial to avoid long-term morbidity, including sexual dysfunction and infertility. Therapy aims to restore serum testosterone to the mid–normal range. Many exciting opportunities remain for further research and therapeutic development.Key words:Acquired hypogonadotropic hypogonadism, thalassemia, iron overload, liver disease.Introduct...
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research
This study aimed at estimation of a panel of the most important related hormones in the serum of patients and illustration of their correlation to the routine laboratory investigations. The four studied hormones showed alteration in the patients in comparison with the controls. While androstenedione, prolactin and testosterone were significantly increased in patients, dehydroepiandrosterone sulphate was decreased. These changes in the hormones were not related to the liver functions, pathological grade or even viral load. We hypothesised a model of how HCV can induce these hormonal changes and recommended to add these horm...
Source: Andrologia - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
More News: Hepatitis | Hepatitis C | Infectious Diseases | Sexual Dysfunction | Study | Virology