Immediate and controlled-release pregabalin for the treatment of epilepsy.

Immediate and controlled-release pregabalin for the treatment of epilepsy. Expert Rev Neurother. 2019 Oct 18;: Authors: Morano A, Palleria C, Citraro R, Nesci V, De Caro C, Giallonardo AT, De Sarro G, Russo E, Di Bonaventura C Abstract Introduction. Epilepsy is a common neurological disease requiring complex therapies, which have been unable to achieve seizure control in 30% of patients. Poor adherence has been recognized as a possible determinant of drug-resistance. Prolonged-release formulations of anti-epileptic drugs might help increase adherence, minimize side effects and pharmacological interactions. Areas Covered. Pregabalin (PGB) has peculiar pharmacodynamics and almost ideal pharmacokinetics, except for a short half-life and therefore requiring multiple daily dosing. PGB immediate-release (IR) is effective in focal-onset epilepsy (FOE), neuropathic pain, generalized anxiety disorder and fibromyalgia, despite some tolerability issues, especially at higher doses. The controlled-release formulation (PGB CR) shares PGB IR advantages and requires slight dose adjustments to guarantee bioavailability. In 2014, PGB CR (165 and 330 mg/day) failed to prove superior to placebo in a randomized placebo-controlled trial on 323 subjects with drug-resistant FOE, although it was just as tolerable. Therefore, PGB CR is not currently licensed for epilepsy. Expert opinion. Considering the disappointing results of the only controlled trial, PGB CR is unlikely to become an est...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research

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CONCLUSIONS: Local application of sevoflurane in the wound bed appears to exhibit analgesic, antimicrobial, and positive healing effects. It could be a promising alternative treatment to be included as a therapeutic option for wound care. PMID: 31730517 [PubMed - in process]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
CONCLUSIONS: This is the largest cohort reported in the literature of patients with frostbite injuries treated with HBOT. Hyperbaric oxygen therapy may show positive impact on the demarcation level of frostbite and, despite the common side effects, it generally causes no long-term sequelae. PMID: 31730511 [PubMed - as supplied by publisher]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
ConclusionsCSU has strong negative effects on female sexual function, especially in patients with angioedema. Additional studies on sexual health in patients with CSU are needed and should focus on the impact of effective treatment on sexual functioning.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
The basic science underlying biological psychiatry came first from animal models. For example, rodent studies established the pathways through which early-life experience and stress impact brain systems involved in anxiety and depression (1). With the advent of modern neuroimaging it became possible to study these systems as they function in healthy humans and in those with psychiatric disorders (2).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is prema...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Stereoelectroencephalography (SEEG) vs.Mindstrong HealthMood Monitoring via Invasive Brain Recordings or Smartphone SwipesWhich Would You Choose?That's not really a fair question. The ultimate goal of invasive recordings is one of direct intervention, by delivering targeted brain stimulation as a treatment. But first you have to establish a firm relationship between neural activity and mood. Well, um, smartphone swipes (the way you interact with your phone) aim to establish a firm relationship between your “digital phenotype” and your mood. And then refer you to an app for a precision intervention. Or to your t...
Source: The Neurocritic - Category: Neuroscience Authors: Source Type: blogs
Conclusions In this case series, SDs were noticed with PGB in 41.33% (n = 31) (men, 13 [50%]; women, 18 [36.73%]), which included erectile dysfunction (n = 16, 51.61%), anorgasmia (n = 10, 32.26%), and loss of libido (n = 11, 35.48%). Sexual dysfunctions occurred within weeks after the use of PGB and were not dose related. They occurred with low therapeutic PGB doses (50–100 mg/d). Discontinuation of PGB resulted in improvement of SDs within weeks. To conclude, SDs are not infrequent adverse effects of PGB therapy. Pregabalin can induce erectile dysfunction, loss of libido, and anorgasmia. Sexual dysfunctions induc...
Source: Clinical Neuropharmacology - Category: Neurology Tags: Original Articles Source Type: research
Conclusion The study underscores the need for regulatory efforts to manage pregabalin abuse, through the addition of pregabalin containing products to the controlled drug list which can’t be purchased without a prescription. Also, pharmacists and customers must be educated at a community pharmacy level regarding potential hazards of pregabalin abuse.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
AbstractPregabalin is currently approved for the treatment of epilepsy, generalized anxiety disorder, neuropathic pain, and fibromyalgia. A qualitative study was undertaken in Jordan, where concerns have been raised about its unprescribed availability in community pharmacies and thereby its abuse. Semi-structured interviews were conducted with all patients with a history of pregabalin use in two Jordanian addiction treatment centers. All were male patients aged 21 –30 years (n = 11). The majority was poly-drug abusers and had a previous history of substance abuse (tramadol, Captagon, synthetic cannabin...
Source: International Journal of Mental Health and Addiction - Category: Addiction Source Type: research
Authors: Calandre EP, Rico-Villademoros F, Slim M Abstract INTRODUCTION: The first two alpha2delta ligands -gabapentin and pregabalin- were initially synthesized as antiepileptics; however, they were later also found to be useful for the treatment of additional conditions. AREAS COVERED: Relevant publications describing potential underlying mechanisms, clinical pharmacokinetics/pharmacokinetics, and clinical efficacy and safety of these drugs in various disease conditions were searched in PubMed and Scopus and included in this review. Expert commentary: Gabapentin and pregabalin are effective for the treatment ...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
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