Early polytherapy for benzodiazepine-refractory status epilepticus

Publication date: Available online 18 October 2019Source: Epilepsy &BehaviorAuthor(s): Jerome Niquet, Lucille Lumley, Roger Baldwin, Franco Rossetti, Mark Schultz, Marcio de Araujo Furtado, Lucie Suchomelova, David Naylor, Ireri Franco-Estrada, Claude G. WasterlainAbstractThe transition from single seizures to status epilepticus (SE) is associated with malaptive trafficking of synaptic gamma-aminobutyric acid (GABAA) and glutamate receptors. The receptor trafficking hypothesis proposes that these changes are key events in the development of pharmacoresistance to antiepileptic drugs (AEDs) during SE, and that blocking their expression will help control drug-refractory SE (RSE).We tested this hypothesis in a model of SE induced by very high-dose lithium and pilocarpine (RSE), and in a model of SE induced by sc soman. Both models are refractory to benzodiazepines when treated 40 min after seizure onset. Our treatments aimed to correct the loss of inhibition because of SE-associated internalization of synaptic GABAA receptors (GABAAR), using an allosteric GABAAR modulator, sometimes supplemented by an AED acting at a nonbenzodiazepine site. At the same time, we reduced excitation because of increased synaptic localization of NMDA and AMPA (?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and N-methyl-D-aspartate) receptors (NMDAR, AMPAR (?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, N-methyl-D-aspartate receptors)) with an NMDAR channel blocker, since A...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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In this study, we analyzed and compared the intestinal microbiota composition of patients with idiopathic focal epilepsy (n = 30) and healthy volunteer group (n = 10) by 16s ribosomal DNA sequencing. Proteobacteria phylum was found to be higher in patients with epilepsy (25.4%) than in healthy volunteers group (1.5%). The genera of Campylobacter, Delftia, Haemophilus, Lautropia, Neisseria among Proteobacteria phylum were found to be statistically significantly higher in patients with epilepsy than in healthy volunteers (p 
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
o A. An Guettarda speciosa is known in traditional folk medicine for treating cough, cold, sore throat, fever, wounds, epilepsy, and headaches. To discover the scientific pharmacological potential of G. speciosa, we explore its anti-inflammatory, cytotoxicity, and inhibition of amyloid-beta (Aβ) aggregation effects. Cyclooxygenase assay of the G. speciosa CHCl3 (GSC) extract and G. speciosa MeOH (GSM) extract are more selective to COX-1 inhibition with a 50% inhibitory concentration (IC50) of 3.56 μg/mL for the GSC extract and 4.98 μg/mL for the GSM extract. Neuroblastoma SH-SY5Y inhibition and t...
Source: Molecules - Category: Chemistry Authors: Tags: Communication Source Type: research
Bassem Sadek Epilepsy is a multifaceted neurological disorder which severely affects neuronal function. Some patients may experience status epilepticus (SE), a life-threatening state of ongoing seizure activity linked to cognitive dysfunction, necessitating an immediate intervention. The potential of histamine H3 receptors in several neuropsychiatric diseases including epilepsy is well recognized. In the current study, we aimed to explore the effect of H3R antagonist E177 on prevention and termination of pilocarpine (PLC)-induced SE in rats as well as evaluating the effects of E177 on the levels of oxidative stress in ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
The platform provides games, music and meditation tools.  
Source: mobihealthnews - Category: Information Technology Source Type: news
A build-up of cholesterol in the brains of people with a severe form of epilepsy can cause prolonged seizures, but it may be possible to treat this with statins
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
ConclusionsThe safety profile of retigabine in adults with POS across four open-label studies was generally consistent with data from previous placebo-controlled studies. Discoloration of various tissues occurred in a proportion of patients treated with retigabine and resolved completely in a small number of these patients following treatment discontinuation. In addition, comprehensive eye examination identified a new adverse reaction of acquired vitelliform maculopathy in a limited number of patients.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Rachael Rosales, Barbara Dworetzky, Gaston BasletAbstractBackgroundPrevious literature suggests that cognitive-emotion processing contributes to the pathogenesis of psychogenic nonepileptic seizures (PNES). Characterization of alterations in cognitive-emotion processing in PNES could inform treatment.MethodsIn this descriptive, cross-sectional study, 143 patients with video electroencephalogram (EEG) confirmed PNES were prospectively recruited. Patients completed self-report questionnaires on emotion perception (Trait Meta-Mood Scale (TMMS) ...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 13 November 2019Source: Epilepsy &BehaviorAuthor(s): Simon ShorvonAbstractAs part of the anniversary issue of Epilepsy &Behavior looking back as aspects of the history of epilepsy, this article reviews psychoanalytical concepts of the pathogenesis of seizures and the so-called epileptic personality (epileptic constitution). It addresses the question whether these theories are completely invalid or do they have insights that are worth rediscovering.Special Issue: Epilepsy &Behavior's 20th Anniversary
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This article is part of the Special Issue “Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures"
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 13 November 2019Source: Epilepsy &BehaviorAuthor(s): Bruce HermannAbstractThis contribution to the commemoration of the 20th anniversary of Epilepsy &Behavior addresses the topic of epilepsy and intelligence, an early focus of interest in the history of the neuropsychology of epilepsy. The path through which the earliest measures of intelligence found their way to epilepsy research is reviewed followed by an overview of the subsequent themes of research, points of disagreement, advances in research using measures of intelligence, and developing awareness of the limitations associa...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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