Multidisciplinary management improves anxiety, depression, medication adherence, and quality of life among patients with epilepsy in eastern China: A prospective study

The objective of this study was to investigate the effect of a multidisciplinary program on anxiety, depression, medication adherence, and quality of life in patients with epilepsy in eastern China.MethodsA cohort of 184 patients with epilepsy from the epilepsy clinic of a tertiary hospital in eastern China completed this program, out of which 92 were randomized into the intervention group and 92 the control group. Patients in both groups received standard antiepileptic drugs (AEDs), while those of the intervention group received an additional 12-month multidisciplinary program developed by a group of the epileptologist, pharmacist, psychiatrist, and epilepsy specialist nurse. Patients were assessed both before and after the 12-month period. The Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), and the eight-item Morisky Medication Adherence Scale (MMAS-8) were used to assess the severity of depression, anxiety, and medication adherence, respectively, along with Quality of life in Epilepsy-31 (QOLIE-31) and self-reported seizure frequency for life quality and seizure severity.ResultsThe 12-month multidisciplinary program significantly reduced the number of patients with severe depression (p = 0.013) and anxiety (p = 0.002), increased the number of patients with moderate-to-high AED adherence (p = 0.006) and the overall QOLIE-31 score (p 
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Sang-Ahm Lee, Ji Ye Jeon, Hyun-Woo KimAbstractPurposeClinical trials have demonstrated the efficacy of perampanel for the treatment of epilepsy. However, patients treated with this and other antiepileptic drugs often exhibit aggressive behaviors. We investigated the clinical factors contributing to aggression in patients with refractory focal epilepsy during 6 months of adjunctive perampanel treatment.MethodsThis was a single-center longitudinal study involving patients treated with perampanel (starting dose, 2 mg/day; maximal dose, 12...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Rachael Rosales, Barbara Dworetzky, Gaston BasletAbstractBackgroundPrevious literature suggests that cognitive-emotion processing contributes to the pathogenesis of psychogenic nonepileptic seizures (PNES). Characterization of alterations in cognitive-emotion processing in PNES could inform treatment.MethodsIn this descriptive, cross-sectional study, 143 patients with video electroencephalogram (EEG) confirmed PNES were prospectively recruited. Patients completed self-report questionnaires on emotion perception (Trait Meta-Mood Scale (TMMS) ...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Abstract BACKGROUND: Previous literature suggests that cognitive-emotion processing contributes to the pathogenesis of psychogenic nonepileptic seizures (PNES). Characterization of alterations in cognitive-emotion processing in PNES could inform treatment. METHODS: In this descriptive, cross-sectional study, 143 patients with video electroencephalogram (EEG) confirmed PNES were prospectively recruited. Patients completed self-report questionnaires on emotion perception (Trait Meta-Mood Scale (TMMS) attention and clarity subscales) and coping style (Affective Styles Questionnaire [ASQ] concealing, adjusting, a...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
This study aimed to evaluate the bioequivalence between two formulations of clonazepam tablets in order to meet regulatory requirements for marketing in Colombia and others countries in Latin America. An open-label, randomized, single-dose, two-period, two-sequence, two-treatment crossover study was conducted in 36 healthy subjects of both genders. Subjects received a single dose of clonazepam 2 mg test tablet (Sanofi-Aventis de Colombia S.A.) and reference product (Rivotril®, Produtos Roche Químicos e Farmacêuticos S.A.) under fasting conditions according to a randomly assigned order with a 21-day ...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Dr. Maryam Shanechi. Credit: USC Viterbi ___________________ Is This the Future of Mental Health? (USC Viterbi School of Engineering): “Brain–machine interfaces (BMIs) provide a direct pathway to the brain to translate brain signals into actions … Below, Shanechi (Note: Maryam Shanechi, PhD, assistant professor of electrical and computer engineering) answers some questions about her work and what the future might hold for our understanding and treatment of mental disorders. What potential does this hold for the future not just of mental health, but of understanding our brains as a whole? Neuropsychiatric...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology brain health brain signals brain-machine interfaces depressive disorders emotion regulation engineering future Maryam Shanechi mental health neural Neuroethics neuropsychiatri Source Type: blogs
AbstractExposure to gestational stress is implicated in increased risk for neuropsychiatric disorders in offspring. We assessed association between prenatal exposure to a 1-month period of repeated rocket attacks during the 2006 Second Lebanon War in Northern Israel and emergence of childhood neuropsychiatric disorders from birth through 9  years of age. Children born to women who were pregnant during the war (N = 6999) were identified and compared to children in the same district born a year later (N = 7054), whose mothers were not exposed to rocket attacks during pregnancy. Multivariable ...
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
ConclusionsChildren born from mothers with epilepsy have an increased risk for emotional disorders. These findings highlight the importance of screening for emotional distress and providing adequate interventions to children born to women with epilepsy.
Source: Seizure - Category: Neurology Source Type: research
ConclusionOverall, patients reported a reduction in anxiety and depressive symptoms over the first 12 months, irrespective of treatment, and baseline level of functioning was the best predictor of outcome. Despite more children achieving seizure freedom with surgery compared with medical treatment, surgery was not associated with better outcomes over time. It may be that changes in anxiety and depression require a longer time to emerge postsurgery; however, being seizure-free is associated with fewer depressive symptoms, irrespective of treatment type.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: December 2019Source: Epilepsy &Behavior, Volume 101, Part AAuthor(s): Su-Hyun Han, Keun Tae Kim, Han Uk Ryu, Sang-Ahm Lee, Yang-Je Cho, Jee Hyun Kim, Kyung-Wook Kang, Dong Jin Shin, Gha Hyun Lee, Kyoung Jin Hwang, Young-Soo Kim, Jung Bin Kim, Ji-Eun Kim, Seo-Young Lee, Jong-Geun SeoAbstractPurposeThe aim of this study was to examine social anxiety in South Korean adults with epilepsy and to identify associated factors.MethodThis was a cross-sectional, multicenter study in South Korea. Social anxiety was assessed using short forms of the Social Phobia Scale (SPS-6) and Social Interaction Anxiety Scale ...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
CONCLUSION: Overall, patients reported a reduction in anxiety and depressive symptoms over the first 12 months, irrespective of treatment, and baseline level of functioning was the best predictor of outcome. Despite more children achieving seizure freedom with surgery compared with medical treatment, surgery was not associated with better outcomes over time. It may be that changes in anxiety and depression require a longer time to emerge postsurgery; however, being seizure-free is associated with fewer depressive symptoms, irrespective of treatment type. PMID: 31677581 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
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