Interval aerobic exercise in individuals with advanced interstitial lung disease: a feasibility study.

Conclusions: Interval exercise was well tolerated and preferred by participants with advanced ILD. PMID: 31625781 [PubMed - as supplied by publisher]
Source: Physiotherapy Theory and Practice - Category: Physiotherapy Authors: Tags: Physiother Theory Pract Source Type: research

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AbstractObjectiveTo assess the efficacy and safety of the Chinese herbTripterygium wilfordii Hook F (TwHF) for the treatment of systemic sclerosis-associated interstitial lung disease (SSc-ILD).MethodsSSc-ILD patients who were regularly treated for more than 1  year and were currently taking a stable dose of TwHF (40–60 mg/day) or CYC (100 mg/day) were selected from the EUSTAR database of Peking Union Medical College Hospital. The efficacy of treatments was assessed by the change in pulmonary function, including the forced vital capacity (FVC) and th e percentage of predicted FVC (FVC pred%).ResultsAmo...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
The objectives of this systematic review were to investigate the role of HRM in the assessment of SSc-associated upper GI involvement and to evaluate the correlation between HRM abnormalities and clinical characteristics and the effects of therapeutic interventions on HRM findings. Fifteen articles were included. Most (11/15) studies were of very good or good quality. Most studies assessed correlations between esophageal symptoms and esophageal dysmotility. Two studies assessed the effectiveness of buspirone and reported HRM findings. Studies assessing upper GI symptoms using validated questionnaires, such as the Universit...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionsIn patients with RA, the relative increase in etanercept-associated risk of experiencing congestive heart failure, serious infection, non-melanoma skin cancer, or interstitial lung disease was similar between elderly and non-elderly.
Source: Drugs and Aging - Category: Geriatrics Source Type: research
ConclusionsHalf of the MDD-CHP patients were diagnosed with CHP using Morisset's CHP diagnostic criteria. Further investigation will be important for developing improved diagnostic criteria for CHP.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
CONCLUSIONS: Long-term post-transplant survival in Northern Spanish patients with CTD-ILD is reduced compared with IPF. PMID: 31694743 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
We presented three cases of patients with SSc, in which High Resolution Computed Tomography examinations showed emphysema with atypical distribution and radiological presentation, without or with mild signs of fibrosing lung disease, that stabilized after immunosuppressive treatment.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Tags: Short communication Source Type: research
ConclusionsNew clinical aspect of diffuse alveolar hemorrhage is first reported to be associated with SAVI. Unsatisfactory therapeutic effects of tofacitinib are observed in this study and further evaluations are needed.
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 6 November 2019Source: Respiratory InvestigationAuthor(s): Kenji Mizumura, Shuichiro Maruoka, Tetsuo Shimizu, Yasuhiro GonAbstractNuclear factor erythroid 2-related factor (Nrf)2 is a transcription factor that integrates cellular stress signals by directing various transcriptional programs. As an evolutionarily conserved intracellular defense mechanism, Nrf2 and its endogenous inhibitor Kelch-like ECH-associated protein (Keap)1 inhibit oxidative stress in the lung, which is the internal organ that is continuously exposed to the environment. Oxidative stress is implicated in the pathogenes...
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
Interstitial lung disease (ILD) is a condition characterized by a higher mortality rate in primary Sj ögren's syndrome (pSS). However, factors influencing the outcome of patients with pSS-associated ILD remain unclear. The aim of the present study was to evaluate predictive factors associated with a worse prognosis in pSS-ILD.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Source Type: research
Granulomatous-lymphocytic interstitial lung disease (GLILD) is a restrictive lung disease, defined as pulmonary tissue containing both granulomatous and lymphoproliferative histopathologic patterns. GLILD is characteristically associated with common variable immune deficiency (CVID), and patients have poorer outcomes. Currently, there is no established standard of care for the treatment of GLILD in CVID.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
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