HIV-induced cancer––all paths leading to rome

ConclusionsTherefore, we infer that serum miRNAs in HIV-1 infection may play important roles in HIV-induced cancer and could be used as a potential biomarker for HIV-cancers detection.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research

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Authors: Panicker RC, Chattopadhaya S, Coyne AG, Srinivasan R Abstract Deregulation of protein kinase activity has been linked to many diseases ranging from cancer to AIDS and neurodegenerative diseases. Not surprisingly, drugging the human kinome - the complete set of kinases encoded by the human genome - has been one of the major drug discovery pipelines. Majority of the approved clinical kinase inhibitors target the ATP binding site of kinases. However, the remarkable sequence and structural similarity of ATP binding pockets of kinases make selective inhibition of kinases a daunting task. To circumvent these iss...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
by Gertrud U. Rey Australian koalas are currently being invaded by koala retrovirus A (KoRV-A), a virus that causes an AIDS-like immunodeficiency and makes infected koalas more susceptible to cancers and opportunistic infections such as chlamydia. Retroviruses owe their name to their replication cycle, because their RNA genomes are reverse transcribed into DNA which is […]
Source: virology blog - Category: Virology Authors: Tags: Basic virology Gertrud Rey Information genome integration koala retrovirus KOR-A piRNA piwi protein retrotransposon rna silencing unspliced RNA viral viruses Source Type: blogs
Sepsis is a healthcare condition with “incredible unmet need,” Ajay Shah, cofounder and CEO of Cytovale, tells MD+DI. “More people die from sepsis than from breast cancer, prostate cancer, and AIDS combined each year, and it costs more than $20 billion a year to treat sepsis in the United States.” Complicating matters is that sepsis “is challenging to diagnose early in the emergency department,” he added. Cytovale is hoping to tackle sepsis through early diagnosis. The company is developing a diagnostic test that cou...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news
Worldwide, health care is becoming more complex and multifaceted. Nurses, who spend more time at the bedside or out in the community with patients and their families than any other health care professional, need leadership-building skills in order to navigate these challenging times. New guidelines focus on interprofessional and holistic care, emphasizing the importance of building leadership skills and abilities. The World Health Organization and the European Association for Palliative Care have shown interest in influencing the development and implementation of palliative care services globally, given the increasingly ag...
Source: Journal of Hospice and Palliative Nursing - Category: Nursing Tags: Feature Articles Source Type: research
Publication date: Available online 1 November 2019Source: Progress in Lipid ResearchAuthor(s): Rebecca C. Gilson, Sachith D. Gunasinghe, Ludger Johannes, Katharina GausAbstractGalectin-3 (Gal3) is a multifaceted protein which belongs to a family of lectins and binds β-galactosides. Gal3 expression is altered in many types of cancer, with increased expression generally associated with poor prognosis. Although the mechanisms remain unknown, Gal3 has been implicated in several biological processes involved in cancer progression, including suppression of T cell-mediated immune responses. Extracellular Gal3 binding to the ...
Source: Progress in Lipid Research - Category: Lipidology Source Type: research
This study demonstrates the need to develop and disseminate educational programs for dental providers so they can assist with efforts to raise HPV vaccination rates. PMID: 31690468 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
By Mary Goodluck Mndeme , Communications officer, IntraHealth International Mary Goodluck Mndeme, Communications Officer for IntraHealth, speaks to Hamisi Kuya about his VMMC experience.November 01, 2019One morning in May 2019, I met Hamisi Kuya (36), a father of two who received voluntary medical male circumcision (VMMC) services through IntraHealth International.Hamisi lives near Kagera, in the northwestern corner of Tanzania, where he has been working at the Kagera Sugar Plantation for some years.In his area, like in many communities in the region, many people believe that the VMMC procedure is very painful and take...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Tags: HIV & AIDS Community Engagement Source Type: news
We describe a case of a diabetic and morbidly obese, but otherwise healthy man, who developed bacteremia and perinephric abscess due to Lactobacillus species.
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Case Reports Source Type: research
Publication date: Available online 31 October 2019Source: International Journal of PharmaceuticsAuthor(s): Mohammadjavad Jahanshahi, Elaheh Kowsari, Vahid Haddadi-Asl, Mehdi Khoobi, Jong Hyun Lee, Firoz Babu Kadumudi, Sepehr Talebian, Nazila Kamaly, Mehdi MehraliAbstractFluorinated graphene has recently gained much attention for cancer drug delivery, owing to its peculiar properties including high electronegativity difference, magnetic resonance imaging contrast agent, and the photothermal effect. However, the hydrophobic nature of fluorinated graphene greatly hinders its application as a biological material. Herein, a nov...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
ConclusionsOur findings are hypothesis generating and highlight the potential safety of major cancer surgery in the HIV population. However, care providers need be cognizant of the potential increased risk of post-operative complications following pulmonary lobectomy and the potential for increased length of stay. These findings are an initial insight into quality of care and outcomes metrics on HIV patients undergoing major cancer operations.
Source: World Journal of Surgery - Category: Surgery Source Type: research
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