Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR.

Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR.
Chem Commun (Camb). 2019 Oct 18;:
Authors: Lau S, Stanhope N, Griffin J, Hughes E, Middleton DA
Abstract
NMR measurements of 19F chemical shift anisotropy and 1H-19F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density lipoprotein (rHDL) nanoparticles, a drug delivery system under clinical investigation.
PMID: 31626247 [PubMed - as supplied by publisher]

Source: Chemical Communications - October 17, 2019 Category: Chemistry Authors: Lau S, Stanhope N, Griffin J, Hughes E, Middleton DA Tags: Chem Commun (Camb) Source Type: research