Formulation of normal tissue irradiation volumes in Co-60 and Ir-192 HDR ICBT of Ca cervix using Total Reference Air Kerma (TRAK)
Publication date: November–December 2019Source: Reports of Practical Oncology &Radiotherapy, Volume 24, Issue 6Author(s): Ngangom Robert, R.P. Chauhan, Arun Oinam, Bhavana RaiAbstractAimThe aim of this study was to formulate isodose volume relations encompassed by isodose surfaces in Co-60 and Ir-192 HDR intracavitary brachytherapy (ICBT) of cervix carcinoma using the Total Reference Air Kerma (TRAK).BackgroundThe TRAK and isodose volumes are radioactive source related. The formulated relations can easily estimate the irradiated isodose volume if the TRAK and dose are known. The C0-60 can also be used for brachytherapy because of its longer half life and comparable OAR doses to Ir-192.Materials and methodsIsodose volumes encompassed by different isodose surfaces and TRAK were obtained from 22 Ca cervix ICBT treatment plans in Co-60 and Ir-192 HDR brachytherapy with 9 Gy prescription to point A. Isodose volume relations were formulated both for Co-60 and Ir-192 brachytherapy source from the slopes and intercepts of the linear fit in the plot between isodose volumes and TRAKs.ResultsThe TRAK value of Co-60 was higher than Ir-192 by about 7.16%. The isodose volumes at low doses for Co-60 were higher than Ir-192. But no significant differences in the dose to the bladder and rectum were observed due to these sources. For dose to 2 cm3 bladder and rectum volume, the differences were 1.07% and 0.75%, respectively. The correlation coefficient with the 2-tailed sig...
ConclusionCombined HDR-B/EBRT for the treatment of clinically localized prostate cancer provides superb clinical outcomes with excellent 5-year bRFS, dMFS, OS, and late GI/GU toxicity rates.
Publication date: Available online 28 October 2019Source: Hepatobiliary &Pancreatic Diseases InternationalAuthor(s): Tian Li, Chong Liu, Jin-Tong He, Kai-Da Sui, Zhou-Bo Zhang, Duo Hong, Hong-Ying Su, Hai-Bo Shao
Conclusion: EF-IMRT is a feasible option for cervical cancer patients with PALN involvement and is associated with acceptable grade III toxicity. Future studies need to focus on minimizing HT toxicity. PMID: 31645885 [PubMed]
CONCLUSIONS: Penile cancer needs demanding surgery to be cured, surrounded by chemotherapy in node positive patients. Lymph nodes involvement is a major prognostic factor. Thus, inguinal node assessment cannot be neglected. PMID: 31610869 [PubMed - in process]
High dose-rate (HDR) brachytherapy for recurrent prostate cancer post-radiotherapy is an accepted salvage method. This prospective non-controlled clinical study investigates HDR-like stereotactic body radiotherapy (SBRT) as a less invasive alternative and evaluates efficacy and toxicity in patients with biopsy proven local recurrence. This method appears clinically feasible, with favorable PSA response, disease control to 5 years in the majority of patients, and acceptably low GU and GI toxicity.
The cover image is based on the Case ReportHigh ‐dose‐rate interstitial brachytherapy for a bulky sebaceous carcinoma of the eyelid: A case report by Yoshiaki Takagawa, Fumihiko Matsumoto, Jun Itami, et al.,https://doi.org/10.1002/ccr3.2360.
CONCLUSIONS: VBT + CT was associated with superior survival outcomes in patients with early-stage serous carcinoma. For non-serous histology, treatment modality was not associated with a difference in survival, although patients with high-grade disease and no nodal dissection experienced benefit from EBRT. PMID: 31610885 [PubMed - as supplied by publisher]
The purpose of this study was to analyze the direct economic impact of two vaginal cuff brachytherapy (VBT) schedules in postoperative endometrial carcinoma (PEC) with similar vaginal control and toxicity results.
CONCLUSIONS: Chemo-brachytherapy is associated with higher acute toxicity with comparable response rates. Small patient numbers and short follow up impedes us from providing conclusive evidence. PMID: 31554360 [PubMed - in process]
Conclusions: The recommended use of imrt with concurrent chemotherapy as an improvement over 3D-crt for management of anal canal carcinoma achieves a high probability of local control and colostomy-free survival without excessive risk for acute or late treatment-related toxicities. PMID: 31548820 [PubMed - in process]